Cor Vasa 2023, 65(5):729-734 | DOI: 10.33678/cor.2023.054

Comparison of cyanoacrylate agents VariClose^® and VenaSeal^™ in the treatment of insufficient saphenous veins

Peter Baláž^{a, b, c}, Slavomír Rokošný^a, Adam Whitley^{a, d}

^a Division of Vascular Surgery, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic

^b Cardiocentre, Third Faculty of Medicine, Charles University, Prague, Czech Republic

^c Department of Vascular Surgery, National Institute of Cardiovascular Diseases, Bratislava, Slovak Republic

^d Department of Anatomy, Second Faculty of Medicine, Charles University, Prague, Czech Republic

Objective: The goal of this study was to compare the cyanoacrylate venous sealing systems VenaSeal^™ and VariClose^® in the treatment of superficial venous insufficiency.

Methods: A single-centre retrospective analysis on patients treated between April 2018 and April 2022 with cyanoacrylate adhesives for lower limb superficial truncal vein insufficiency was performed.

Results: The VariClose^® system was used in 27 patients (30 veins) and the VenaSeal^™ system in 97 patients (125 veins). The median follow-up periods for patients treated with VariClose^® and VenaSeal^™ systems were 267 (IQR 223) and 201 (IQR 280) days, respectively. At one year, recanalization occurred in 11 veins treated with the VariClose^® system and 5 veins treated with the VenaSeal^™ system. The occlusion rates estimated by the Kaplan-Meier method at 30, 90, 180, and 360 days were 100%, 96%, 83%, and 42% for veins treated with the VariClose^® system and 100%, 98%, 96%, and 91% for veins treated with the VenaSeal^™ system (p <0.01).

Conclusions: The VenaSeal^™ system had significantly better occlusion rates than the VariClose^® system.

Keywords: Cyanoacrylate, VariClose^®, Varicose veins, VenaSeal^™ , Venous insufficiency

Received: February 17, 2023; Revised: June 14, 2023; Accepted: June 14, 2023; Published: October 15, 2023  Show citation