Cor Vasa 2020, 62(6):567-573 | DOI: 10.33678/cor.2020.089

Do patients with heart failure and preserved, mid-range or reduced ejection fraction have different outcomes?

Ralitsa Pancheva^a, Svetoslav Yovev^b, Vasil Kolev^a, Blagovest Stoimenov

^a Cardiology Clinic, Department of Internal Diseases "Kirkovich", University Hospital Alexandrovska, Sofia, Bulgaria

^b Department of Electrocardiostimulation and Electrocardiophysiology, University Hospital Saint Ekaterina, Sofia, Bulgaria

Introduction: The therapeutic strategies and prognosis in heart failure with reduced ejection fraction (HFrEF) are well established. However, the prognosis of HF patients with preserved EF (HFpEF) and HF with mid-range EF (HFmrEF) remains not well understood. Purpose: To investigate the risk factors, clinical and echocardiographic characteristics and prognosis of Bulgarian patients with HFpEF, HFmrEF, and HFrEF.

Methods: In this observational study 890 patients were included. All of them were admitted to our Cardiology department between the years 2012 and 2014 for decompensated chronic HF.

Results: The patients with HFpEF (609, 68.4%), HFmrEF (145, 16.3%), and HFrEF (136, 15.3%) were followed up for all-cause mortality and rehospitalizations. The adjusted 5.8 years mortality rate was significantly higher in HFrEF (61.8%) and HFmrEF (55.9%) versus HFpEF (34.6%). After the second year of follow-up the HFrEF patients had a non-significantly reduced survival versus HFmrEF ones. Over a period of 1.2 year the HFrEF and HFmrEF patients had significantly higher risk of readmissions due to decompensated HF (33.7%

Keywords: Heart failure, Mid-range ejection fraction, Mortality, Rehospitalizations

Received: June 25, 2020; Revised: September 21, 2020; Accepted: October 9, 2020; Published: December 11, 2020  Show citation