Cor et Vasa - Latest articles
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Michael Aschermann, Ondřej Aschermann: Historie katetrizací srdceBook reviews
Prof. MUDr. Tomáš Kovárník, Ph.D.
Cor Vasa 2026, 68(1) | DOI: 10.33678/cor.2026.004 
Internista a kardiolog profesor Richard Češka se stal šéfem světové interní medicínyCurrent news
Michael Aschermann
Cor Vasa 2026, 68(1) | DOI: 10.33678/cor.2026.009
Pan profesor MUDr. Jiří Vítovec, CSc., FESC, slaví životní jubileumPersonalia
Michael Aschermann
Cor Vasa 2026, 68(1) | DOI: 10.33678/cor.2026.008
Zemřel dětský kardiolog a intenzivista primář MUDr. Jaroslav Wiedermann, CSc. (6. 4. 1949–4. 12. 2025)Personalities
Prof. MUDr. Eva Klásková, Ph.D., MHA; MUDr. Sabina Kaprálová, Ph.D.; MUDr. Alžběta Palátová
Cor Vasa 2026, 68(1) | DOI: 10.33678/cor.2026.010
Opustil nás profesor Jan Petrášek (8. 9. 1929–12. 2. 2026)Personalities
Michael Aschermann
Cor Vasa 2026, 68(1) | DOI: 10.33678/cor.2026.015
Relationship of Neutrophil-Lymphocyte Ratio (NLR) as Diagnostics and Prognostics Tools of Deep Vein Thrombosis (DVT): Current StatusReview articles
Zanella Yolanda Lie, Yan Efrata Sembiring
Cor Vasa 2026, 68(1):119-122 | DOI: 10.33678/cor.2025.081
The neutrophil-lymphocyte ratio (NLR) has emerged as a promising biomarker in deep vein thrombosis (DVT), reflecting the intricate relationship between inflammation and thrombosis. This literature review examines NLR's dual role as both a diagnostic and prognostic tool in DVT management. Current evidence demonstrates that elevated NLR (>3.0) correlates strongly with DVT occurrence, severity, and recurrence risk, particularly in high-risk populations such as postoperative and cancer patients. Mechanistically, NLR captures the pro-thrombotic effects of neutrophil extracellular traps (NETs) and the anti-thrombotic regulation by lymphocytes, offering...
Klippel-Trénaunay syndrome: the etiology, clinical presentation, and treatment optionsReview articles
Mária Rašiová, Martin Koščo, Marek Hudák, Veronika Pavlíková, Adriana Rašiová, Marta Bavoľárová
Cor Vasa 2026, 68(1):111-118 | DOI: 10.33678/cor.2025.106
Objective: Klippel-Trénaunay syndrome (KTS) is a combined slow-flow vascular malformation associated with excessive growth of limbs. The aim of this review is to summarize the knowledge about the presumed etiology, the most common anomalies associated with KTS, the diagnostic approach, and the treatment strategies. Methods: A literature search was conducted between January and May 2025 using PubMed and Google Scholar databases, focusing on terms such as Klippel-Trénaunay syndrome and PIK3CA-related overgrowth spectrum (PROS). Conclusions: KTS manifests as a cluster of congenital malformations affecting the limb and typically affects the lower...
(Physical activity and exercise in the prevention of coronary heart disease: implications for clinical practice)Review articles
Ladislav Baťalík, Bogna Jiravská Godula, Libor Jelínek, Eliška Sovová
Cor Vasa 2026, 68(1):100-110 | DOI: 10.33678/cor.2025.099
Cardiovascular diseases represent a significant global health problem. Regular physical activity and exercise are among the most effective interventions for primary and secondary prevention. Epidemiological data show that even low to moderate levels of regular physical activity reduce cardiovascular mortality and morbidity. The underlying mechanisms include favorable changes in traditional risk factors and direct vascular effects. Conversely, physical inactivity is associated with increased cardiovascular risk and overall mortality. In secondary prevention, participation in structured cardiac rehabilitation programs significantly reduces the risk of...
(Anticoagulation in Maintenance Dialysis Patients with Atrial fibrillation - Consensus Expert Opinion of the Czech Society of Nephrology and the Czech Society of Cardiology)Expert consensus statement
Štěpán Havránek, Ivan Rychlík, Kryštof Rückl, Eliška Dvořáčková, Pavel Osmančík, Petr Peichl, Alena Paříková, Martin Havrda, Vladimír Tesař, Petr Ošťádal
Cor Vasa 2026, 68(1):87-99 | DOI: 10.33678/cor.2026.001
Atrial fibrillation is a frequent arrhythmia in patients with end-stage renal disease and on maintenance dialysis treatment. In the general population, anticoagulation therapy is indicated in patients with arrhyth- mia to prevent cardioembolic complications. In the case of end-stage kidney disease and hemodialysis, the treatment is challenging due to the lack of data or contraindications of some anticoagulants. Patients with advanced chronic kidney disease and patients on hemodialysis are at high risk not only for ischemic cardioembolic events but also for a higher incidence of bleeding complications. This paper aims to describe the criteria for initiation...
(Cardiac resynchronisation therapy in children and patients with congenital heart disease: a review article)Review articles
Michal Vrbík, Tereza Zmatlíková, Olena Jurčenko, Jan Kovanda, Miroslav Ložek, Jan Janoušek
Cor Vasa 2026, 68(1):78-85 | DOI: 10.33678/cor.2025.121
This review addresses the issue of cardiac resynchronization therapy (CRT) in pediatric and congenital heart disease (CHD) patients with heart failure caused by systolic dysfunction and electromechanical dyssynchrony. Heart failure is one of the leading causes of long-term morbidity and mortality in patients with CHD. Approximately 600-700 children with CHD are born each year in the Czech Republic. Most of them require interventional therapy. A number of cardiac surgical procedures results in electromechanical dyssynchrony caused either by bundle branch block or conventional ventricular pacing. CRT presents an integral part of heart failure therapy...
(Beta-blockers in patients after myocardial infarction with ejection fraction 41-49%?)Review articles
Radek Pudil
Cor Vasa 2026, 68(1):73-77 | DOI: 10.33678/cor.2025.130
Beta-blocker therapy is one of the fundamental pillars of pharmacological treatment for patients after myocardial infarction with reduced ejection fraction. It has been shown that the benefit of this therapy decreases as the ejection fraction increases. Recently, results from several studies (REBOOT-CNIC, BETAMI, DANBLOCK, and CAPITAL-RCT) and their meta-analysis have been presented, providing very favorable data demonstrating the benefit of beta-blocker therapy in patients with mildly reduced left ventricular ejection fraction. According to this analysis, a lower incidence of monitored outcomes (all-cause mortality, new myocardial infarction, or heart...
(Impact of Methodology on the Estimated Prevalence of Primary Hyperaldosteronism in Apparently Resistant Hypertension)Review articles
Tomáš Kvapil, Eva Kociánová, Zdeněk Ramík, Jan Olšr, Jan Vácha, Libor Jelínek, Jan Václavík
Cor Vasa 2026, 68(1):66-72 | DOI: 10.33678/cor.2025.091
Objective: The aim of this review is to summarize current knowledge on the prevalence of primary hyperaldosteronism (PHA) in patients with apparently resistant hypertension (aRH) and to critically analyze the methodological factors influencing the estimation of this prevalence. Methods: A review of the available literature was conducted, focusing on studies assessing the prevalence of PHA in patients with resistant hypertension. Methodological differences between studies were analyzed, including definitions of resistant hypertension, thresholds for the aldosterone-renin ratio (ARR), use of confirmatory tests, management of interfering antihypertensive...
(Acoramidis: another treatment option for transthyretin cardiac amyloidosis)Review articles
Tomáš Paleček
Cor Vasa 2026, 68(1):61-65 | DOI: 10.33678/cor.2025.131
Transthyretin amyloidosis (ATTR) of the heart is a progressive and ultimately fatal disease characterized by the deposition of insoluble amyloid fibrils, derived from the misfolded protein transthyretin (TTR), in the myocardium. In the Czech Republic, wild-type ATTR cardiomyopathy (ATTRwt) dominates, typically affecting individuals older than 65 years. The hereditary form of ATTR (ATTRv) is probably rare in our country. In the last 15 years, there has been a significant development in the field of specific, disease-modifying treatment of ATTR cardiomyopathy. This therapy focuses either on influencing TTR synthesis in the liver (suppressors of TTR formation),...
Pilot Evaluation of Endothelin-1 and TG/HDL-C Ratio for Early Cardiovascular Risk Stratification in Adiposity-Based and Cardiovascular-Kidney-Metabolic SyndromesOriginal research articles
Aldian Arie Pratama, Agustin Iskandar, Singgih Pudjo Wahono
Cor Vasa 2026, 68(1):51-60 | DOI: 10.33678/cor.2025.085
Adiposity-related chronic diseases and cardiovascular-kidney-metabolic (CKM) syndrome significantly contribute to the burden of non-communicable diseases (NCDs), especially in low- and middle-income countries (LMICs), where early risk stratification is still inadequate. This study evaluated the efficacy of endothelin-1 (ET-1) and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio as early, cost-efficient biomarkers for cardiovascular risk assessment in persons with adiposity-based chronic disease (ABCD) and early-stage CKM syndrome. An analytical experimental investigation was performed on persons aged 30 to 65 years with ABCD...
Predictors and Outcomes of No-reflow among Acute ST-Segment Elevation Myocardial Infarction PatientsOriginal research articles
Beshoy Yacoub, Amir Anwer Shaker, Sameh El-Kaffas, Mohammed El Ramly, Mohamed A. Abdelwahab
Cor Vasa 2026, 68(1):43-50 | DOI: 10.33678/cor.2025.087
Background: The no-reflow phenomenon (NRP) can occur in up to 40% of patients after primary percutaneous coronary intervention (PPCI) for acute ST-segment elevation myocardial infarction (STEMI). NRP significantly diminishes the benefits of reperfusion therapy, leading to increased infarct size and poorer outcomes. Although the exact pathophysiology of non-reperfusion injury (NRP) is not fully understood, various factors may contribute to it through different mechanisms. Aim: In this study, we aim to investigate clinical and interventional predictors of no-reflow and their impact on in-hospital outcomes among a cohort of acute STEMI patients presenting...
Autonomic Nervous System Imbalance Reflected by Reduced Heart Rate Variability in Patients with Coronary Slow FlowOriginal research articles
Okan Tanriverdi
Cor Vasa 2026, 68(1):39-42 | DOI: 10.33678/cor.2025.080
Background: Coronary slow flow (CSF) is an angiographic entity characterized by delayed contrast progres- sion in coronary arteries without significant epicardial obstruction. Autonomic dysregulation has been sug- gested as a potential contributor to its pathophysiology. Heart rate variability (HRV) is a validated, non-invasive tool for assessing autonomic function. Objective: To evaluate alterations in HRV parameters among patients with CSF and to explore the potential role of autonomic nervous system imbalance in its pathogenesis. Methods: This cross-sectional study included 50 patients with CSF and 50 age- and sex-matched controls with normal coronary...
Comparing Patient-Reported Quality of Life in Leadless Pacemakers versus Conventional Pacemakers: A Systematic ReviewOriginal research articles
Moses Orvin Reviano, Rerdin Julario
Cor Vasa 2026, 68(1):31-38 | DOI: 10.33678/cor.2025.072
Background: Conventional pacemakers (C-PM) are recommended for permanent pacemaker implantation, but developments have led to leadless pacemakers (L-PM). Evolving clinical guidelines support quality of life (QoL) in pacemaker selection, with L-PM hypothesized to offer better QoL by minimizing lead-based complications, but variability in patient selection criteria complicates this. This systematic review aims to compare patient-reported QoL in L-PM versus C-PM. Methods: A literature search was done on PubMed, EMBASE, Cochrane CENTRAL, Science Direct, Scopus, ProQuest, Google Scholar, and Wiley Online Library from 2015 to 2025. Included studies compared...
Clinical Spectrum and Risk Factors for Heart Failure in Very Young PatientsOriginal research articles
Yogi Puji Rachmawan, Witri Pratiwi, Fawzia Haznah Nurul Imani, Helda, Bambang Budi Siswanto, Nurhayati Adnan
Cor Vasa 2026, 68(1):24-30 | DOI: 10.33678/cor.2025.070
Background: The prevalence of heart failure (HF) in younger individuals is rising, challenging the traditional perception of HF as a disease of older adults. This trend carries significant clinical and economic implications, as HF requires lifelong management, leading to increased healthcare costs and reduced productivity. Objective: This study aims to investigate the clinical spectrum and underlying risk factors of HF patients at young age. Method: This case-control design study was conducted at HF Clinic of Hasna Medika Hospital in Cirebon. The case group were HF patients aged 17-40 years who were examined at outpatient clinic or admitted to hospital...
Comparative study of lead placement in the right ventricular apex vs. right ventricular outflow tract: effects on left ventricular systolic dysfunction, dilatation, and myocardial performance - a single-center experienceOriginal research articles
Rerdin Julario, Ruth Irena Gunadi, Makhyan Jibril Al-Farabi, Rumman Karimah, Budi Baktijasa Dharmadjati, I Gde Rurus Suryawan, Yudi Her Oktaviono
Cor Vasa 2026, 68(1):16-23 | DOI: 10.33678/cor.2025.096
Aim: This study aims to analyze the difference of right ventricular (RV) apex and right ventricular outflow tract (RVOT) pacing with the incidence of left ventricular (LV) systolic dysfunction, LV dilatation, and left ventricular myocardial performance index (LVMPI) after 2 years of implantation. Methods: This is an analytic observational study with a retrospective cohort design. The study subjects were patients using single-chamber RV pacing permanent pacemaker (PPM) after 2 years of implantation at Soetomo Surabaya General Hospital. We collected baseline characteristic data, electrocardiogram, and PPM burden. Subsequently, LVMPI, cardiac chamber...
Speckle Tracking Echocardiography: The Secret Key To Predicting Poor Outcomes in Infective EndocarditisOriginal research articles
Ahmed A. Elamragy, Juliette Bahgat Mesak, Wael Mohamed Elnaggar, Karim Said, Marwa Sayed Meshaal
Cor Vasa 2026, 68(1):8-15 | DOI: 10.33678/cor.2025.104
Objectives: To investigate speckle-tracking echocardiography's role in detecting subclinical myocardial dysfunction in infective endocarditis (IE) patients and predicting in-hospital outcomes. Methods: We prospectively enrolled 46 patients with active IE. Blood cultures and serology tests were performed, and blood samples for total leucocytic count, C-reactive protein (CRP), and procalcitonin were col- lected at multiple intervals. Serial conventional transthoracic echocardiography with speckle tracking was also performed. Results: Most patients had right-sided IE linked to intravenous drug use. Despite preserved left ventricular ejection fraction...
ECPR Prague School, Cubex Centrum Prague, October 16–18, 2025Reports
redakce
Cor Vasa 2025, 67(Suppl.5)
Czech Cardiovascular Research and Innovation Day 2025 & 11th European Section meeting of the International Academy of Cardiovascular SciencesReports
redakce
Cor Vasa 2025, 67(Suppl.4)
Prague, November 2–4, 2025
Special supplement of the Cor et Vasa journal focused on case reportsEditorial
Michael Aschermann
Cor Vasa 2025, 67(Suppl.3):i | DOI: 10.33678/cor.2025.088
Late-onset acute limb ischemia after transcatheter patent foramen ovale closure with Occlutech Figulla Flex II PFO OccluderCase reports
Juraj Dúbrava, Maria Hajzoková, Erika Drangová, Ivo Gašparovič
Cor Vasa 2025, 67(Suppl.3):89-92 | DOI: 10.33678/cor.2025.078
Background: Thrombus formation is an exceedingly rare complication after transcatheter patent foramen ovale (PFO) occlusion. To the best of the authors' knowledge, a case of late symptomatic thrombosis of Occlutech Figulla Flex II PFO occluder has not yet been published. Case presentation: A 45-year-old man with a history of peripheral artery embolism, and subsequent PFO closure with Occlutech Figulla Flex II PFO occluder. The patient completed dual antiplatelet therapy with clopidogrel (75 mg/day) and aspirin (100 mg/day) after 6 months and subsequently continued single antiplatelet therapy (SAPT) with clopidogrel for other eight months. Five...
Giant Right Ventricle Myxoma Presenting as Right Heart Failure - a Case ReportCase reports
Štefan Lukačín, Tomáš Toporcer, Vilém Rohn, Pavel Kočan, Anton Bereš, Marián Homola, Michal Trebišovský, Adrián Kolesár
Cor Vasa 2025, 67(Suppl.3):83-88 | DOI: 10.33678/cor.2025.034
Introduction: Primary cardiac tumors are generally a very rare condition, with an incidence of only 0.0001% to 0.3% in autopsies. Despite the fact that myxoma is the most common primary heart tumor, fewer than 5% of myxomas, which vary in size, occur in the ventricles. Case report: A 19-year-old patient with an unremarkable medical history presented with a one-month history of exertional dyspnea, fatigue, facial edema, and palpitations. Echocardiography recorded a mass measur- ing 60 × 70 mm in the right ventricle, spontaneous echo contrast in the right atrium, a maximum blood flow velocity in the pulmonary trunk of 3 m/s, enlargement of right atrium...
From weak knees to a troubled heart - a case of severe autonomic dysfunction in Guillain-Barré syndromeCase reports
Adriana Pacheco, Leandra Fagundes, José Beato Coelho, Raquel Ferreira, Ana Briosa
Cor Vasa 2025, 67(Suppl.3):80-82 | DOI: 10.33678/cor.2025.017
Guillain-Barré Syndrome (GBS) is an autoimmune inflammatory disease of the peripheral nervous system, often preceded by respiratory or gastrointestinal infection. A serious complication is autonomic dysfunction, particularly cardiovascular, manifesting as blood pressure fluctuations, arrhythmias, and electrocardiographic changes. Myocardial infarction is rare and its diagnosis may be challenging in this setting. We report the case of a 67-year-old man with a recent upper respiratory infection who presented with progressive weakness of the lower limbs. He rapidly developed tetraparesis, dysphagia, respiratory failure, and acute pulmonary edema, accompanied...
A Rare Case of Carotidynia: Aneurysm and Kinking of the Left Internal Carotid ArteryCase reports
Ali Maksut Aykut, Metin Onur Beyaz, Okan Eren Kuguoglu, Didem Melis Oztas, Murat Ugurlucan
Cor Vasa 2025, 67(Suppl.3):76-79 | DOI: 10.33678/cor.2025.043
Chronic neck pain can be attributed to various etiologies, including carotidynia, a relatively rare condition characterized by pain in the region overlying the carotid artery attributed to underlying vascular pathologies. In this case report, we present the case of a 47-year-old female patient who experienced chronic neck pain and was diagnosed with left internal carotid artery aneurysm and kinking. Surgical reconstruction was performed, resulting in a successful outcome without neurological complications. This case highlights the importance of early diagnosis and appropriate surgical intervention of an aneurysm and kinking of the left internal carotid...
Thoracic aortic aneurysm with an aberrant right subclavian artery and truncus bicaroticusCase reports
Carlos Daniel Quintana Baños, Štefan Lukačín, Tomáš Toporcer, Adrián Kolesár, Matej Moščovič, Peter Šafár
Cor Vasa 2025, 67(Suppl.3):71-75 | DOI: 10.33678/cor.2025.036
Introduction: Arteria lusoria, or aberrant right subclavian artery (ARSA), is an anomaly of origin of the supra-aortic branches with an estimated incidence of 0.2-1.7%. 8% of these patients with ARSA go on to develop a thoracic aortic aneurysm, in contrast to 4.4% of the population without an aortic arch anomaly. Case report: This case report presents a 56-year-old male, without associated comorbidities, who presented with an aortic arch anomaly composed of a truncus bicaroticus with a concomitant aberrant right subclavian artery without Komerell diverticulum and with a retroesophageal course, in association with an extensively calcified saccular aneurysm...
Surgical correction of partial anomalous pulmonary venous return in a patient with persistent left superior vena cava: cannulation techniques and challengesCase reports
Andrej Domonkos, Panagiotis Artemiou, Štefan Durdík, Ivo Gašparovič, Michal Hulman
Cor Vasa 2025, 67(Suppl.3):68-70 | DOI: 10.33678/cor.2025.023
Partial anomalous pulmonary venous return (PAPVR) associated with a sinus venosus atrial septal defect (SVASD) and a persistent left superior vena cava (PLSVC) presents significant surgical challenges. These anomalies require careful planning of cardiopulmonary bypass (CPB) and venous cannulation strategies. A 38-year-old woman presented with a history of supraventricular tachycardia (SVT) and a hemodynamically significant left-to-right shunt (Qp : Qs = 1.87) due to SVASD and PAPVR. Preoperative imaging revealed drainage of the right upper pulmonary vein into the PLSVC. The patient underwent successful surgical cor- rection using the double-patch technique...
Chronic Venous Insufficiency in a 55-Year-Old Female: Highlighting Overlooked Cases for Increased AwarenessCase reports
Nathania Nathania, Fadhilah Mahrus Tauhid, Jesselyn Wijaya, Attaillah Moza, Al Fatih Muhammad Ismail, Georaldhy Yussufy Caecarma, Niko Azhari Hidayat
Cor Vasa 2025, 67(Suppl.3):63-67 | DOI: 10.33678/cor.2025.014
Introduction: Chronic venous insufficiency (CVI) is a prevalent condition characterized by impaired venous flow leading to venous hypertension. This dysfunction often results from valve failure due to varicose veins, deep vein damage, or vein wall weakness influenced by altered collagen and elastin. CVI manifests as dilated veins, leg edema, pain, and skin changes. Despite its significant impact, CVI remains underdiagnosed and undertreated, often progressing to postphlebitic syndrome and venous ulcers. This study aims to highlight the prevalence of CVI in this high-risk population and to provide insights into effective preventive measures and management...