Cor Vasa 2026, 68(1):100-110 | DOI: 10.33678/cor.2025.099

(Physical activity and exercise in the prevention of coronary heart disease: implications for clinical practice)

Ladislav Baťalíka-d, Bogna Jiravská Godulae, Libor Jelínekf, Eliška Sovováf
a Katedra fyzioterapie a rehabilitace, Lékařská fakulta Masarykovy univerzity, Brno, Česká republika
b Rehabilitační klinika, Fakultní nemocnice Brno, Brno, Česká republika
c Rehabilitační klinika, Lékařská fakulta Masarykovy univerzity, Brno, Česká republika
d Ústav veřejného zdraví, Lékařská fakulta Masarykovy univerzity, Brno, Česká republika
e Centrum sportovní kardiologie, Kardiocentrum, Nemocnice AGEL Třinec-Podlesí, Třinec, Česká republika
f Centrum sportovní kardiologie, Klinika tělovýchovného lékařství a kardiovaskulární rehabilitace, Lékařská fakulta Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc, Olomouc, Česká republika

Cardiovascular diseases represent a significant global health problem. Regular physical activity and exercise are among the most effective interventions for primary and secondary prevention. Epidemiological data show that even low to moderate levels of regular physical activity reduce cardiovascular mortality and morbidity. The underlying mechanisms include favorable changes in traditional risk factors and direct vascular effects. Conversely, physical inactivity is associated with increased cardiovascular risk and overall mortality. In secondary prevention, participation in structured cardiac rehabilitation programs significantly reduces the risk of reinfarction, hospitalizations, and mortality. Initial screening and individual exercise prescription following the "Frequency, Intensity, Time, Type - Progression (FITT-P)" principles are essential for the safety and effectiveness of these interventions. Both continuous and interval exercise modalities are used in practice, emphasizing individual choice based on clinical status and patient preference. Modern digital technologies facilitate remote rehabilitation and home-based programs, overcoming common participation barriers and improving adherence. Tracking daily step counts can serve as a simple and motivating indicator for the general population, with even small increases delivering significant health benefits. Effective implementation of physical activity in clinical practice requires a multidisciplinary approach, continuous patient and healthcare provider education, and active use of available technologies, potentially significantly improving the prognosis of patients with coronary heart disease.

Keywords: Cardiac rehabilitation, Coronary heart disease, Exercise, Physical activity, Prevention

Received: August 4, 2025; Revised: September 4, 2025; Accepted: September 8, 2025; Prepublished online: June 2, 2012; Published: March 15, 2026  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Baťalík L, Jiravská Godula B, Jelínek L, Sovová E. (Physical activity and exercise in the prevention of coronary heart disease: implications for clinical practice). Cor Vasa. 2026;68(1):100-110. doi: 10.33678/cor.2025.099.
Download citation

References

  1. Naghavi M, Ong KL, Aali A, et al. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the global burden of Disease Study 2021. Lancet 2024;403:2100-2132. Go to original source... Go to PubMed...
  2. Národní kardiovaskulární plán ČR (NKVP 2035). Souhrnná analytická studie (2024) Praha: Ministerstvo zdravotnictví České republiky; 2025. 213 p. Online. Dostupné z: https://mzd.gov.cz/wp-content/uploads/2025/01/Priloha-3_NKV_plan-souhrnna-analyticka-studie.pdf. [citováno 2026-02-01].
  3. Global Cardiovascular Risk Consortium; Magnussen C, Ojeda FM, et al. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. N Engl J Med 2023;389:1273-1285. Go to original source...
  4. Anand SS, Islam S, Rosengren A, et al.; INTERHEART Investigators. Risk factors for myocardial infarction in women and men: insights from the INTERHEART study. Eur Heart J 2008;29:932-940. Go to original source... Go to PubMed...
  5. Vrablík M, Cífková R, Tuka V, Linhart A. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Summary of the document prepared by the Czech Society of Cardiology. Cor Vasa 2022;64:165-211. Go to original source...
  6. Isath A, Koziol KJ, Martinez MW, et al. Exercise and cardiovascular health: A state-of-the-art review. Prog Cardiovasc Dis 2023;79:44-52. Go to original source... Go to PubMed...
  7. Tian D, Meng J. Exercise for Prevention and Relief of Cardiovascular Disease: Prognoses, Mechanisms, and Approaches. Oxid Med Cell Longev 2019;2019:3756750. Go to original source...
  8. Ikonomidis I, Vlastos D, Andreadou I, et al. Vascular conditioning prevents adverse left ventricular remodelling after acute myocardial infarction: a randomised remote conditioning study. Basic Res Cardiol 2021;116:9. Go to original source...
  9. Lippi G, Henry BM, Sanchis-Gomar F. Physical inactivity and cardiovascular disease at the time of coronavirus disease 2019 (COVID-19). Eur J Prev Cardiol 2020;27:906-908. Go to original source... Go to PubMed...
  10. Lee IM, Shiroma EJ, Lobelo F, et al.; Lancet Physical Activity Series Working Group. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 2012;380:219-229. Go to original source...
  11. Banach M, Lewek J, Surma S, et al. The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis. Eur J Prev Cardiol 2023;30:1975-1985. Erratum in: Eur J Prev Cardiol 2023;30:2045. Go to original source... Go to PubMed...
  12. Lavie CJ, Ozemek C, Carbone S, et al. Sedentary Behavior, Exercise, and Cardiovascular Health. Circ Res 2019;124:799-815. Go to original source...
  13. Franklin BA, Eijsvogels TMH, Pandey A, et al. Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part II: Physical activity, cardiorespiratory fitness, minimum and goal intensities for exercise training, prescriptive methods, and special patient populations. Am J Prev Cardiol 2022;12:100425. Go to original source... Go to PubMed...
  14. Haskell WL, Lee IM, Pate RR, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 2007;39:1423-1434. Go to original source...
  15. Kunutsor SK, Laukkanen JA. Physical activity, exercise and adverse cardiovascular outcomes in individuals with pre-existing cardiovascular disease: a narrative review. Expert Rev Cardiovasc Ther 2024;22:91-101. Go to original source... Go to PubMed...
  16. Moxley E, Habtzghi D. A Systematic Review Comparing Dose Response of Exercise on Cardiovascular and All-Cause Mortality. Home Health Care Management & Practice 2019;31:263-273. Go to original source...
  17. Alves AJ, Viana JL, Cavalcante SL, et al. Physical activity in primary and secondary prevention of cardiovascular disease: Overview updated. World J Cardiol 2016;8:575-583. Go to original source...
  18. Redfern J, Gallagher R, O'Neil A, et al. Historical Context of Cardiac Rehabilitation: Learning From the Past to Move to the Future. Front Cardiovasc Med 2022;9:842567. Go to original source... Go to PubMed...
  19. Tardo DT, Papadakis M. Are the Cardiovascular Benefits and Potential Risks of Physical Activity and Exercise Dependent on Race, Ethnicity, or Sex? Can J Cardiol 2025;41:456-469. Go to original source... Go to PubMed...
  20. Kahler CW, Spillane NS, Day AM, et al. Positive Psychotherapy for Smoking Cessation: A Pilot Randomized Controlled Trial. Nicotine Tob Res 2015;17:1385-1392. Go to original source... Go to PubMed...
  21. Mora S, Cook N, Buring JE, et al. Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms. Circulation 2007;116:2110-2118. Go to original source... Go to PubMed...
  22. Chomiuk T, Niezgoda N, Mamcarz A, Śliż D. Physical activity in metabolic syndrome. Front Physiol. 2024;15:1365761. Go to original source...
  23. Hayes P, Ferrara A, Keating A, et al. Physical Activity and Hypertension. Rev Cardiovasc Med 2022;23:302. Go to original source...
  24. Pinckard K, Baskin KK, Stanford KI. Effects of Exercise to Improve Cardiovascular Health. Front Cardiovasc Med 2019;6:69. Go to original source...
  25. Clark K, Sharp S, Womack CJ, et al. Increased sedentary time and decreased physical activity increases lipoprotein associated phospholipase A2 in obese individuals. Nutr Metab Cardiovasc Dis 2022;32:1703-1710. Go to original source... Go to PubMed...
  26. Koushki K, Shahbaz SK, Mashayekhi K, et al. Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways. Clin Rev Allergy Immunol 2021;60:175-199. Go to original source...
  27. Tucker WJ, Fegers-Wustrow I, Halle M, et al. Exercise for Primary and Secondary Prevention of Cardiovascular Disease: JACC Focus Seminar 1/4. J Am Coll Cardiol 2022;80:1091-1106. Go to original source... Go to PubMed...
  28. Lee DC, Sui X, Church TS, et al. Changes in fitness and fatness on the development of cardiovascular disease risk factors hypertension, metabolic syndrome, and hypercholesterolemia. J Am Coll Cardiol 2012;59:665-672. Go to original source...
  29. Williams PT. Vigorous exercise, fitness and incident hypertension, high cholesterol, and diabetes. Med Sci Sports Exerc 2008;40:998-1006. Go to original source... Go to PubMed...
  30. Tuka V, Jiravský O, Kubuš P, Sovová E. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Summary of the document prepared by the Czech Society of Cardiology. Cor Vasa 2021;63:235-262. Go to original source...
  31. Zváč M, Baťalík L. (Changes in Body Composition During Outpatient and Hybrid Cardiovascular Rehabilitation in Patients with Coronary Artery Disease). Cor Vasa 2025;67:336-343. Go to original source...
  32. Pelliccia A, Sharma S, Gati S, et al.; ESC Scientific Document Group. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J 2021;42:17-96. Erratum in: Eur Heart J 2021;42:548-549. Go to original source...
  33. Taylor RS, Dalal HM, McDonagh STJ. The role of cardiac rehabilitation in improving cardiovascular outcomes. Nat Rev Cardiol 2022;19:180-194. Go to original source... Go to PubMed...
  34. Winnige P, Vysoky R, Dosbaba F, Batalik L. Cardiac rehabilitation and its essential role in the secondary prevention of cardiovascular diseases. World J Clin Cases 2021;9:1761-1784. Go to original source... Go to PubMed...
  35. Dibben GO, Faulkner J, Oldridge N, et al. Exercise-based cardiac rehabilitation for coronary heart disease: a meta- -analysis. Eur Heart J 2023;44:452-469. Go to original source...
  36. Molloy C, Long L, Mordi IR, et al. Exercise-based cardiac rehabilitation for adults with heart failure. Cochrane Database Syst Rev 2024;3:CD003331. Go to original source...
  37. Keteyian SJ, Jackson SL, Chang A, et al. Tracking Cardiac Rehabilitation Utilization in Medicare Beneficiaries: 2017 UPDATE. J Cardiopulm Rehabil Prev 2022;42:235-245. Go to original source... Go to PubMed...
  38. Winnige P, Filakova K, Hnatiak J, et al. Validity and Reliability of the Cardiac Rehabilitation Barriers Scale in the Czech Republic (CRBS-CZE): Determination of Key Barriers in East- -Central Europe. Int J Environ Res Public Health 2021;18:13113. Go to original source...
  39. Sugiharto F, Nuraeni A, Trisyani Y, et al. Barriers to Participation in Cardiac Rehabilitation Among Patients with Coronary Heart Disease After Reperfusion Therapy: A Scoping Review. Vasc Health Risk Manag 2023;19:557-570. Go to original source... Go to PubMed...
  40. Varghese T, Schultz WM, McCue AA, et al. Physical activity in the prevention of coronary heart disease: implications for the clinician. Heart 2016;102:904-909. Go to original source... Go to PubMed...
  41. Ruzzolini M, Ambrosetti M. Cardiopulmonary exercise testing in cardiac rehabilitation: From the reporting form to structured exercise prescription. A proposal from the Italian alliance for cardiovascular rehabilitation and prevention (Itacare-P). Int J Cardiol Cardiovasc Risk Prev 2023;18:200191. Go to original source...
  42. Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2021;144:e368-e454. Go to original source... Go to PubMed...
  43. Gianrossi R, Detrano R, Mulvihill D, et al. Exercise-induced ST depression in the diagnosis of coronary artery disease. A meta-analysis. Circulation 1989;80:87-98. Go to original source... Go to PubMed...
  44. Vrints C, Andreotti F, Koskinas KC, et al; ESC Scientific Document Group. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J 2024;45:3415-3537. Erratum in: Eur Heart J 2025;46:1565. Go to original source... Go to PubMed...
  45. Taylor JL, Myers J, Bonikowske AR. Practical guidelines for exercise prescription in patients with chronic heart failure. Heart Fail Rev 2023;28:1285-1296. Go to original source... Go to PubMed...
  46. Keteyian SJ, Squires RW, Ades PA, Thomas RJ. Incorporating patients with chronic heart failure into outpatient cardiac rehabilitation: practical recommendations for exercise and self-care counseling-a clinical review. J Cardiopulm Rehabil Prev 2014;34:223-232. Go to original source...
  47. Woods E, Bennett J, Chandrasekhar S, et al. Efficacy of Diagnostic Testing of Suspected Coronary Artery Disease: A Contemporary Review. Cardiology 2025;150:111-132.
  48. Bonikowske AR, Taylor JL, Larson KF, et al. Evaluating current assessment techniques of cardiorespiratory fitness. Expert Rev Cardiovasc Ther 2024;22:231-241. Go to original source...
  49. Hansen D, Abreu A, Ambrosetti M, et al. Exercise intensity assessment and prescription in cardiovascular rehabilitation and beyond: why and how: a position statement from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology. Eur J Prev Cardiol 2022;29:230-245. Go to original source... Go to PubMed...
  50. Knuuti J, Wijns W, Saraste A, et al.; ESC Scientific Document Group. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J 2020;41:407-477. Go to original source... Go to PubMed...
  51. Saraste A, Barbato E, Capodanno D, et al. Imaging in ESC clinical guidelines: chronic coronary syndromes. Eur Heart J Cardiovasc Imaging 2019;20:1187-1197. Go to original source...
  52. Grace SL, Turk-Adawi KI, Contractor A, et al. Cardiac Rehabilitation Delivery Model for Low-Resource Settings: An International Council of Cardiovascular Prevention and Rehabilitation Consensus Statement. Prog Cardiovasc Dis 2016;59:303-322. Go to original source...
  53. Milani JGPO, Milani M, Verboven K, et al. Exercise intensity prescription in cardiovascular rehabilitation: bridging the gap between best evidence and clinical practice. Front Cardiovasc Med 2024;11:1380639. Go to original source... Go to PubMed...
  54. Saba MA, Goharpey S, Attarbashi Moghadam B, et al. Correlation Between the 6-Min Walk Test and Exercise Tolerance Test in Cardiac Rehabilitation After Coronary Artery Bypass Grafting: A Cross-sectional Study. Cardiol Ther 2021;10:201-209. Go to original source... Go to PubMed...
  55. Nevelikova M, Dosbaba F, Pepera G, et al. Validity and reliability of automated treadmill six-minute walk test in patients entering exercise-based cardiac rehabilitation. Ann Med 2023;55:2304664. Go to original source... Go to PubMed...
  56. Abreu A, Mendes M, Dores H, et al. Mandatory criteria for cardiac rehabilitation programs: 2018 guidelines from the Portuguese Society of Cardiology. Rev Port Cardiol (Engl Ed) 2018;37:363-373. English, Portuguese. Go to original source...
  57. Su JJ, Batalik L, Candelaria D. One size does not fit all: socio-cultural considerations for cardiac rehabilitation. Eur J Cardiovasc Nurs 2025 May 5:zvaf068. doi: 10.1093/eurjcn/zvaf068. Epub ahead of print. Go to original source... Go to PubMed...
  58. Verdicchio C, Freene N, Hollings M, et al. A Clinical Guide for Assessment and Prescription of Exercise and Physical Activity in Cardiac Rehabilitation. A CSANZ Position Statement. Heart Lung Circ 2023;32:1035-1048. Go to original source... Go to PubMed...
  59. Kohzuki M. Multimorbidity and Multiple Disabilities: Present Status and the Roles of Rehabilitation. J Clin Med 2024;13:6351. Go to original source... Go to PubMed...
  60. Bull FC, Al-Ansari SS, Biddle S, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med 2020;54:1451-1462. Go to original source...
  61. Carter SJ, Baranauskas MN, Ballinger TJ, et al. Exercise load monitoring: integrated approaches to advance the individualisation of exercise oncology. BMJ Open Sport Exerc Med 2021;7:e001134. Go to original source... Go to PubMed...
  62. Mytinger M, Nelson RK, Zuhl M. Exercise Prescription Guidelines for Cardiovascular isease Patients in the Absence of a Baseline Stress Test. J Cardiovasc Dev Dis 2020;7:15. Go to original source... Go to PubMed...
  63. Bell LR, Worn R, O'Grady MW, et al. Progressive overload in cardiorespiratory exercise training for young and old: Is increasing duration or intensity of exercise more important? Medical Hypotheses 2024;188:111366. Go to original source...
  64. Costache AD, Maștaleru A, Leon MM, et al. High-Intensity Interval Training vs. Medium-Intensity Continuous Training in Cardiac Rehabilitation Programs: A Narrative Review. Medicina (Kaunas) 2024;60:1875. Go to original source...
  65. Yu H, Zhao X, Wu X, et al. High-intensity interval training versus moderate-intensity continuous training on patient quality of life in cardiovascular disease: a systematic review and meta-analysis. Sci Rep 2023;13:13915. Go to original source... Go to PubMed...
  66. Serrablo-Torrejon I, Lopez-Valenciano A, Ayuso M, et al. High intensity interval training exercise-induced physiological changes and their potential influence on metabolic syndrome clinical biomarkers: a meta-analysis. BMC Endocr Disord 2020;20:167. Go to original source... Go to PubMed...
  67. Ko JM, So WY, Park SE. Narrative Review of High-Intensity Interval Training: Positive Impacts on Cardiovascular Health and Disease Prevention. J Cardiovasc Dev Dis 2025;12:158. Go to original source... Go to PubMed...
  68. Ellingsen Ø, Halle M, Conraads V, et al.; SMARTEX Heart Failure Study (Study of Myocardial Recovery After Exercise Training in Heart Failure) Group. High-Intensity Interval Training in Patients With Heart Failure With Reduced Ejection Fraction. Circulation 2017;135:839-849. Go to original source... Go to PubMed...
  69. Makita S, Yasu T, Akashi YJ, et al. Japanese Circulation Society/the Japanese Association of Cardiac Rehabilitation Joint Working Group. JCS/JACR 2021 Guideline on Rehabilitation in Patients With Cardiovascular Disease. Circ J 2022;87:155-235. Erratum in: Circ J 2023;87:937. Go to original source... Go to PubMed...
  70. Ghazavi S, Zavar R, Sadeghi M, et al. Comparing the Effect of Moderate-Intensity Versus High-Intensity Interval Training Exercise on Global Longitudinal Strain (GLS) in Cardiovascular Patients: Systematic Review and Meta-Analysis. Cardiol Res Pract 2025;2025:9901472. Go to original source... Go to PubMed...
  71. Franklin BA, Quindry J. High level physical activity in cardiac rehabilitation: Implications for exercise training and leisure- -time pursuits. Prog Cardiovasc Dis 2022;70:22-32. Go to original source...
  72. Paluch AE, Boyer WR, Franklin BA, et al; on behalf the American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; and Council on Peripheral Vascular Disease. Resistance Exercise Training in Individuals With and Without Cardiovascular Disease: 2023 Update: A Scientific Statement From the American Heart Association. Circulation 2024;149:e217-e231. Go to original source... Go to PubMed...
  73. Adam CA, Erskine J, Akinci B, et al. Exercise Training and Cardiac Rehabilitation in Patients After Percutaneous Coronary Intervention: Comprehensive Assessment and Prescription. J Clin Med 2025;14:1607. Go to original source... Go to PubMed...
  74. Yamamoto S, Matsunaga A, Wang G, et al. Effect of balance training on walking speed and cardiac events in elderly patients with ischemic heart disease. Int Heart J 2014;55:397-403. Go to original source...
  75. Dimitriadis N, Panagiotakos D. Aerobic or Resistance Exercise for maximum Cardiovascular Disease Protection? An Appraisal of the Current Level of Evidence. J Prev Med Hyg 2024;65:E323-E329.
  76. Ferguson T, Olds T, Curtis R, et al. Effectiveness of wearable activity trackers to increase physical activity and improve health: a systematic review of systematic reviews and meta-analyses. Lancet Digit Health 2022;4:e615-e626. Go to original source... Go to PubMed...
  77. Paluch AE, Bajpai S, Ballin M, et al.; Steps for Health Collaborative. Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis. Circulation 2023;147:122-131. Go to original source... Go to PubMed...
  78. Hall KS, Hyde ET, Bassett DR, et al. Systematic review of the prospective association of daily step counts with risk of mortality, cardiovascular disease, and dysglycemia. Int J Behav Nutr Phys Act 2020;17:78. Go to original source... Go to PubMed...
  79. Jayedi A, Gohari A, Shab-Bidar S. Daily Step Count and All-Cause Mortality: A Dose-Response Meta-analysis of Prospective Cohort Studies. Sports Med 2022;52:89-99. Go to original source... Go to PubMed...
  80. Stens NA, Bakker EA, Mañas A, et al. Relationship of Daily Step Counts to All-Cause Mortality and Cardiovascular Events. J Am Coll Cardiol 2023;82:1483-1494. Go to original source... Go to PubMed...
  81. Su JJ, Wong AK, Zhang LP, et al. Technology-assisted cardiac rehabilitation for coronary heart disease patients with central obesity: a randomized controlled trial. Eur J Phys Rehabil Med 2024;60:95-103. Go to original source... Go to PubMed...
  82. Su JJ, Wong AKC, He XF, et al. Feasibility and effectiveness of cardiac telerehabilitation for older adults with coronary heart disease: A pilot randomized controlled trial. Contemp Clin Trials Commun 2024;42:101365. Go to original source... Go to PubMed...
  83. Su JJ, Paguio JT, Wang W, Batalik L. Designing a Nurse- -Led eHealth Cardiac Rehabilitation Program: Insights From Participant Experiences and Qualitative Feedback. Public Health Nurs 2025;42:144-153. Go to original source... Go to PubMed...
  84. Bassett DR Jr, Toth LP, LaMunion SR, Crouter SE. Step Counting: A Review of Measurement Considerations and Health-Related Applications. Sports Med 2017;47:1303-1315. Go to original source... Go to PubMed...
  85. Morrow JR Jr, Defina LF, Leonard D, et al. Meeting physical activity guidelines and musculoskeletal injury: the WIN study. Med Sci Sports Exerc 2012;44:1986-1992. Go to original source... Go to PubMed...
  86. Vanhees L, Geladas N, Hansen D, et al. Importance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular risk factors: recommendations from the EACPR. Part II. Eur J Prev Cardiol 2012;19:1005-1033. Go to original source... Go to PubMed...
  87. Armstrong M, Paternostro-Bayles M, et al. Preparticipation Screening Prior to Physical Activity in Community Lifestyle Interventions. Transl J Am Coll Sports Med 2018;3:176-180. Go to original source... Go to PubMed...
  88. Franklin, Barry A.; Eijsvogels, Thijs M. H.1. A Narrative Review on Exercise and Cardiovascular Disease: Physical Activity Thresholds for Optimizing Health Outcomes. Heart and Mind 2023;7:34-39. Go to original source...
  89. Scheinowitz M, Harpaz D. Safety of cardiac rehabilitation in a medically supervised, community-based program. Cardiology 2005;103:113-117. Go to original source... Go to PubMed...
  90. Antoniou V, Kapreli E, Davos CH, et al. Safety and long- -term outcomes of remote cardiac rehabilitation in coronary heart disease patients: A systematic review. Digit Health 2024;10:20552076241237661. Go to original source... Go to PubMed...
  91. Pham HN, Abdelnabi MH, Ibrahim R, et al. Exercise and Atrial Fibrillation: Current Evidence, Knowledge Gaps, and Future Directions. Rev Cardiovasc Med 2025;26:39200. Go to original source... Go to PubMed...
  92. Hsieh PN, Shen S, Chukwurah MI, et al. Athlete's Heart Revisited: Historical, Clinical, and Molecular Perspectives. Circ Res 2025;137:231-254. Go to original source... Go to PubMed...
  93. Opondo MA, Aiad N, Cain MA, et al. Does High-Intensity Endurance Training Increase the Risk of Atrial Fibrillation? A Longitudinal Study of Left Atrial Structure and Function. Circ Arrhythm Electrophysiol 2018;11:e005598. Go to original source... Go to PubMed...
  94. Hsu JJ, Tintut Y, Demer LL. Paradox of Exercise and Coronary Artery Calcification: Potential Underlying Mechanisms. Circ Res 2025;137:335-349. Go to original source... Go to PubMed...
  95. Arbab-Zadeh A, Perhonen M, Howden E, et al. Cardiac remodeling in response to 1 year of intensive endurance training. Circulation 2014;130:2152-2161. Go to original source... Go to PubMed...
  96. Javed W, Botis I, Goh ZM, et al. Ventricular Arrhythmia and Cardiac Fibrosis in Endurance Experienced Athletes (VENTOUX). Circ Cardiovasc Imaging 2025:e018470. doi: 10.1161/CIRCIMAGING.125.018470. Epub ahead of print. Go to original source... Go to PubMed...
  97. Eberly L, Garg L, Vidula M, et al. Running the Risk: Exercise and Arrhythmogenic Cardiomyopathy. Curr Treat Options Cardiovasc Med 2021;23:64. Go to original source... Go to PubMed...
  98. Antoniou V, Davos CH, Kapreli E, et al. Effectiveness of Home- -Based Cardiac Rehabilitation, Using Wearable Sensors, as a Multicomponent, Cutting-Edge Intervention: A Systematic Review and Meta-Analysis. J Clin Med 2022;11:3772. Go to original source... Go to PubMed...
  99. Blioumpa C, Karanasiou E, Antoniou V, et al. Efficacy of supervised home-based, real time, videoconferencing telerehabilitation in patients with type 2 diabetes: a single- -blind randomized controlled trial. Eur J Phys Rehabil Med 2023;59:628-639. Go to original source... Go to PubMed...
  100. Thomas RJ, Beatty AL, Beckie TM, et al. Home-Based Cardiac Rehabilitation: A Scientific Statement From the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology. J Am Coll Cardiol 2019;74:133-153. Go to original source... Go to PubMed...
  101. Su JJ, Yu DSF, Paguio JT. Effect of eHealth cardiac rehabilitation on health outcomes of coronary heart disease patients: A systematic review and meta-analysis. J Adv Nurs 2020;76:754-772. Go to original source... Go to PubMed...
  102. McDonagh ST, Dalal H, Moore S, et al. Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev 2023;10:CD007130. Go to original source... Go to PubMed...
  103. Stefanakis M, Batalik L, Papathanasiou J, et al. Exercise-based cardiac rehabilitation programs in the era of COVID-19: a critical review. Rev Cardiovasc Med 2021;22:1143-1155. Go to original source... Go to PubMed...
  104. Baťalík L. (Cardiovascular telerehabilitation: remotely monitored physical exercise). Cor Vasa 2021;63:79-85. Go to original source...
  105. Golbus JR, Lopez-Jimenez F, Barac A, et al. Digital Technologies in Cardiac Rehabilitation: A Science Advisory From the American Heart Association. Circulation 2023;148:95-107. Go to original source... Go to PubMed...
  106. Batalik L, Filakova K, Sladeckova M, et al. The cost- -effectiveness of exercise-based cardiac telerehabilitation intervention: a systematic review. Eur J Phys Rehabil Med 2023;59:248-258. Go to original source... Go to PubMed...
  107. Su JJ, Lin R, Batalik L, Wong AKC, Grace SL. Psychological eHealth Interventions for Patients With Cardiovascular Diseases: Systematic Review and Meta-Analysis. J Med Internet Res 2025;27:e57368. Go to original source... Go to PubMed...
  108. Minchin K, Landers MR. Effects of a physical therapist-driven individualized hybrid model of the exercise component of cardiac rehabilitation on patient outcomes: a prospective single group, time-series design. Disabil Rehabil 2025;47:1163-1175. Go to original source...

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.