Evaluation of an effect of profundoplasty on peripheral tissue perfusion in patients with peripheral arterial disease using transcutaneous oximetry

Dominik Maduda, Luboš Kubíček, Katěrina Bílá, Robert Staffa

Cor Vasa 2024, 66(5):474-480 | DOI: 10.33678/cor.2024.065  

Introduction: Profunda femoris artery (PFA) is an important artery that provides perfusion of the lower limb tissues via collateral circulation in case of superficial femoral artery (SFA) occlusion. Isolated angiovascular reconstruction, APF reconstruction (profundoplasty), is a debated topic in the scientific literature regard- ing the importance of collateral circulation and its contribution to improving the patient's clinical condi- tion. This project aims to evaluate the impact of isolated profundoplasty on the improvement of lower limb perfusion and thus to contribute to the decision-making process for the indication of this type of procedure....

(Intra-individual variability of lipoprotein(a) and its potential impact on treatment decisions regarding this risk factor)

Tereza Nezbedová, Otto Mayer Jr.

Cor Vasa 2024, 66(5):481-486 | DOI: 10.33678/cor.2024.064  

Introduction: Lipoprotein(a) represents a virtually overlooked risk factor for which targeted treatment may be available soon. It has been suggested that Lp(a) concentrations are stable over time and need to be mea- sured only once in a lifetime. We aimed to verify this in clinical practice. Methods: The study includes 490 patients in whom Lp(a) was repeatedly collected, and we assessed its intra-individual variability. Results: A total of 1657 individual Lp(a) determinations were performed, with a median of 3 examinations/patient and an interval between the first/last determination of 1.1 years. The mean coefficient of variability (CVi, ratio of the...

(The role of the catchment cardiologist - adults with congenital heart disease)

Radka Hazuková

Cor Vasa 2024, 66(5):488-494 | DOI: 10.33678/cor.2024.068  

Aim: To describe the role of the catchment cardiologist and to map the real practice in his catchment outpatient clinic related to adults with congenital heart diseases (CHD). Material and methods: A cohort of adults with CHD was selected by a retrospective analysis of the electronic database of adults in the catchment cardiologist's outpatient clinic for a 7-year period. Unambiguous cases were included. Uncertain cases and cases not meeting the criteria of CHD (valvular abnormalities without haemodynamic defects, persistent foramen ovale, arrhythmia, cardiomyopathy) were excluded. Results: Of the total number of examined adults (N = 2338, age 63.7±16.2...

Extremity Ischemia after Peripheral Vascular Intervention in Newborns with Congenital Heart Disease: Our Single Center Experience

Kenan Abdurrahman Kara, Ergin Arslanoğlu, Fatih Yiğit, Eylem Tunçer, Nihat Çine, Hakan Ceyran

Cor Vasa 2024, 66(5):495-499 | DOI: 10.33678/cor.2024.067  

Background: Acute limb ischemia (ALI) is a rare but serious condition that can cause significant lifetime morbidity or mortality in the pediatric population. It is usually post-traumatic or iatrogenic. Results: In the study, 127 newborns who were followed up with arterial monitoring in our intensive care unit between 2019-2021 were screened retrospectively. Invasive arterial monitoring was performed on the upper extremities in 83 patients and the lower extremities in 44 patients. Acute extremity ischemia was observed in three (6%) patients who underwent lower extremity monitoring and eight (9%) patients with upper extremity ischemia. Primarily, extremity...

The Correlation of Level of Surgical Risk with High Sensitivity Cardiac Troponin in Non-Cardiac Surgical Patients

Desak Ketut Sekar Cempaka Putri, Mochamad Yusuf Alsagaff, Budi Susetyo Pikir, Muhamad Robiul Fuadi

Cor Vasa 2024, 66(5):500-505 | DOI: 10.33678/cor.2024.052  

Background: Myocardial injury after non-cardiac surgery (MINS) is an important issue, directly related to the mortality rate within 30 days after surgery. High sensitivity cardiac troponin (HS troponin) is the preferred biomarker for diagnosing myocardial damage because it is the most sensitive and specific heart biomarker currently available, making it suitable for detecting MINS. The aim of this study is to analyse the relationship between changes in HS troponin levels and surgery-related risks in non-cardiac surgery patients as a marker of myocardial injury. Method: This study is an analytical observational cross sectional study that included all...

Arterial hypertension and significant DNA damage - from cell lines to patients

Radka Hazuková

Cor Vasa 2024, 66(5):506-511 | DOI: 10.33678/cor.2024.075  

Arterial hypertension (HT) is a key risk factor and a widespread chronic disease that contributes to the development of a number of cardiac and non-cardiac diseases. Therefore, HT is one of the important causes of morbidity, disability, and mortality. The aetiology of HT is multifactorial. Oxidative stress appears to be the main driver in the aetiology of HT and other cardiovascular diseases (CVD). The role of DNA damage is newly discussed in the context of oxidative stress and in the genesis of CVD with a view to new therapeutic targets. Regarding current guidelines with defined gaps in the evidence, the aim of this paper was to present a comprehensive...

(Coarctation of the aorta in a newborn with mitral and aortic valve anomalies)

Mariana Perušičová, Viktor Tomek, Václav Chaloupecký, Jan Janoušek

Cor Vasa 2024, 66(5):512-517 | DOI: 10.33678/cor.2024.050  

Coarctation of the aorta is one of the most common congenital heart defects with usually favourable intermediate and long-term prognosis. Coarctation of the aorta is often associated with other heart congenital defects, especially obstructive lesions of the left-sided cardiac structures. The combination of aortic coarctation with a borderline left ventricle, mitral and/or aortic valve anomalies or stenosis is associated with a higher risk of reintervention or early mortality. One-third of infants with coarctation require urgent management in the neonatal period, and most infants experience normal growth of the initially smaller left ventricle after...

Cardiovascular Risk Assessment in Chronic Obstructive Pulmonary Disease Patients

Anastasiia Melenevych, Olga Melenevych

Cor Vasa 2024, 66(5):518-524 | DOI: 10.33678/cor.2024.051  

Prevention of adverse cardiovascular (CV) events is a challenging part of managing patients with chronic obstructive pulmonary disease (COPD). Common pathophysiological mechanisms are a prerequisite for the mutual burden of comorbid pathology, COPD, and cardiovascular diseases (CVD). Controversies in the assessment of traditional CV risk factors, untimely detection of existing CVD, heterogeneity of the course of COPD, and the influence of COPD medications on CV risk - all these indicate the need for additional clarifications regarding the assessment of CV risk in patients with COPD. This review summarizes recent studies on CV risk assessment in patients...

Time to change the family diagnosis: Arrhythmogenic left ventricular cardiomyopathy

Michaela Veselá, Gabriela Dostálová, Zuzana Hlubocká, Petr Kuchynka, Vladimír Tuka, Tomáš Kovárník, Martin Mašek, Aleš Linhart

Cor Vasa 2024, 66(5):525-528 | DOI: 10.33678/cor.2024.033  

Arrhythmogenic cardiomyopathy is an inherited cardiomyopathy characterized by fibrofatty replacement and a high risk of ventricular arrhythmias and sudden cardiac death. This myocardial disorder is typically transmitted through autosomal dominant pattern and caused by pathogenic variants in the desmosomal and extradesmosomal genes. In this case, we are presenting a family with three members who have arrhythmogenic left ventricular cardiomyopathy. The condition was found to be caused by a nonsense mutation (c.1754 T>G (p. Leu585Ter)) in the desmoplakin (DSP) gene. Unfortunately, two of the family members were initially misdiagnosed and treated for...

(Complex treatment and its complications in a patient with hypertrophic cardiomyopathy)

Zuzana Holubcová, Matej Strýček, Rostislav Polášek, Pavol Tomašov

Cor Vasa 2024, 66(5):529-533 | DOI: 10.33678/cor.2024.066  

Hypertrophic cardiomyopathy is a genetic disorder characterized by increased left ventricle thickness greater than 15 milimetres in the absence of any other explanatory cause. The diagnostics and treatment of patients with hypertrophic cardiomyopathy include search for a management of left ventricular outflow tract obstruction, risk stratification for sudden cardiac death and genetic testing and screening of family members. This case report describes a young man with a chronic skin disease on permanent biological therapy who had a family history of sudden cardiac death and had recently been diagnosed with hypertrophic cardiomyopathy with symptomatic...

A rare case of cardiac arrest caused by hyponatremia

Michal Kalina, Dominik Flak, Jan Beneš

Cor Vasa 2024, 66(5):534-538 | DOI: 10.33678/cor.2024.057  

Hyponatremia, characterized by sodium levels below 135 mmol/l, is the most prevalent electrolyte disorder worldwide. It presents with a wide range of clinical symptoms, particularly in the neurological and gastrointestinal domains, occasionally leading to cardiac arrhythmias. In our specific case, severe hyponatremia resulting from potomania resulted in sinus bradycardia with alternating atrioventricular block and subsequent cardiac arrest. Restoration of sinus rhythm was achieved following correction of the sodium levels. However severe hyponatremia and long-lasting CPR resulted in brain oedema, which ultimately led to brain death. Per national regulations,...

Connection of superior vena cava to left atrium in a newborn followed with unexplained mild cyanosis

Mehmet Turan Basunlu, Gizem Sari, Emre Oteyaka, Mehmet Sait Dogan, Turkay Saritas, Abdullah Erdem, Chousein Amet, Abdullah Sert, Didem Melis Oztas, Gamze Demirel, Halil Turkoglu, Murat Ugurlucan

Cor Vasa 2024, 66(5):539-542 | DOI: 10.33678/cor.2024.034  

Abnormal drainage of the superior vena cava into the left atrium is a rare congenital cardiac malformation. It leads to cyanosis due to right-to-left shunt. In this report we present the management strategy of a 43-day-old baby who was investigated for mild cyanosis since birth and was diagnosed with superior vena cava draining into the left atrium.

An unusual case of left-sided hemitruncus arteriosus associated with aortic arch hypoplasia

Hande Akilli, Hadeil Alhashmi, Aslan Babayigit, Serap Yucel, Didem Melis Oztas, Murat Ugurlucan, Emin Tireli

Cor Vasa 2024, 66(5):543-545 | DOI: 10.33678/cor.2024.035  

Hemitruncus arteriosus is among the rarest congenital cardiovascular defects. Pathology usually involves the right pulmonary artery. It may occur either isolated or associated with other cardiac defects such as septal defects and tetralogy of Fallot; however, it is seldom associated with aortic arch pathologies. We represent an unusual case of a 15-day-old neonate with left-sided hemitruncus arteriosus associated with aortic arch hypoplasia, coarctation of the aorta, patent ductus arteriosus, and craniofacial abnormalities, who underwent surgical correction.

Daniel E. Lieberman: Příběh lidského těla. Evoluce, zdraví a nemoci

Prof. MUDr. Jan Petrášek, DrSc.

Cor Vasa 2024, 66(5):556  

Pan profesor Jan Petrášek slaví 95. narozeniny

Michael Aschermann, Jaromír Hradec

Cor Vasa 2024, 66(5):548  

Průkopník české kardiologie, prof. MUDr. Michael Aschermann, DrSc., slaví osmdesáté narozeniny

Aleš Linhart, Petr Widimský, Jiří Vítovec

Cor Vasa 2024, 66(5):549-551  

Významné životní jubileum profesorky Zuzany Moťovské

Petr Widimský, Michael Aschermann

Cor Vasa 2024, 66(5):552-553  

Sedmdesát let primáře MUDr. Ladislava Grocha, Ph.D.

Michael Aschermann, Jiří Vítovec a Lenka Špinarová

Cor Vasa 2024, 66(5):554-555