Cor Vasa 2024, 66(5):506-511 | DOI: 10.33678/cor.2024.075

Arterial hypertension and significant DNA damage - from cell lines to patients

Radka Hazuková^{a, b}

^a Department of Internal Medicine I - Cardiology, University Hospital Olomouc, Olomouc, Faculty of Medicine, Palacký University in Olomouc and University Hospital Olomouc, Olomouc, the Czech Republic

^b Department of Cardiology and Internal Medicine (Profi-Kardio, s.r.o.), Horice v Podkrkonosi, the Czech Republic

Arterial hypertension (HT) is a key risk factor and a widespread chronic disease that contributes to the development of a number of cardiac and non-cardiac diseases. Therefore, HT is one of the important causes of morbidity, disability, and mortality. The aetiology of HT is multifactorial. Oxidative stress appears to be the main driver in the aetiology of HT and other cardiovascular diseases (CVD). The role of DNA damage is newly discussed in the context of oxidative stress and in the genesis of CVD with a view to new therapeutic targets. Regarding current guidelines with defined gaps in the evidence, the aim of this paper was to present a comprehensive form of studies on significant types of DNA damage in HT - from cell cultures to real patients.

Keywords: DNA damage and breaks, DNA damage repair, Gaps in the evidence, Guidelines, Hypertension, Oxidative stress, PARP

Received: August 9, 2024; Revised: September 9, 2024; Accepted: September 30, 2024; Prepublished online: June 2, 2012; Published: October 25, 2024  Show citation