Cor Vasa 2024, 66(4):403-410 | DOI: 10.33678/cor.2024.016

Investigation of Heart Rate Variability and Ventricular Repolarization Indexes in Brucella Patients with Palpitations

Okan Tanriverdia, Lutfu Askinb, Husna Sengul Askinc, Serdar Turkmend
a Department of Cardiology, Siirt Education and Research Hospital, Siirt, Turkey
b Department of Cardiology, Gaziantep Islamic Science and Technology University, Gaziantep, Turkey
c Department of Infectious Diseases, Ersin Arslan Education and Research Hospital, Gaziantep, Turkey
d Department of Cardiology, Adiyaman University, Adiyaman, Turkey

Background: Global zoonotic diseases like brucellosis increase cardiac mortality and malignant arrhythmias. Heart rate variability (HRV) measures heart rate non-invasively and reliably. Lower HRV suggests autonomic dysfunction. The Tp-e/QT interval (QT) and corrected QT (QTc) ratios are used to detect ventricular arrhyth- mogenesis.

Objective: In brucellosis, we examined the relationship between autonomic dysfunction and ventricular repolarization (VR). This was done noninvasively by assessing HRV and VR parameters.

Methods: One hundred patients with brucellosis had a mean age of 39.2±1.1 years. One hundred healthy volunteers with a mean age of 44.3 years made up the control group, which was age and sex matched. We calculated and recorded Tp-e, QT, QTc, and Tp-e/QTc, as well as HRV values.

Results: Brucellosis patients had considerably greater QTmax, QTcmax, QTmin, and QTcmin than controls. Tp-e, cTp-e, Tp-e/QTc, and Tp-e dispersion ratios were significantly greater in brucellosis patients compared to the control group (80.2±4.4 and 73.8±5.4, p <0.001; 87.5±6.2 and 82.6±7.8, p = 0.001; 0.20±0.01 and 0.21±0.01, p = 0.004; 29.4±11.9 and 21.7±10.2. Patients with brucellosis had greater LF/HF ratios during daylight and overnight (p <0.001). Daytime and nighttime LF/HF ratios were favourably linked with Tpe_cQT (r = 0.700, p <0.001, and r = 0.746, p <0.001, respectively).

Conclusions: On electrocardiography, brucellosis patients had longer Tp-e intervals, QT ratios, and QTc ratios. Brucellosis patients had increased HRV traits, including the LF/HF ratio. LF/HF and Tp-e/QTc correlated favourably. Brucellosis may cause subclinical cardiac engagement and autonomic dysfunction. These pa- tients need more ventricular arrhythmia screening.

Keywords: Brucellosis, Heart rate variability, High frequency power, low frequency power Tp-e interval Tp-e, QT ratio

Received: January 18, 2024; Revised: January 18, 2024; Accepted: February 23, 2024; Prepublished online: June 2, 2012; Published: September 9, 2024  Show citation

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Tanriverdi O, Askin L, Askin HS, Turkmen S. Investigation of Heart Rate Variability and Ventricular Repolarization Indexes in Brucella Patients with Palpitations. Cor Vasa. 2024;66(4):403-410. doi: 10.33678/cor.2024.016.
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