Cor Vasa 2024, 66(3):328-334 | DOI: 10.33678/cor.2024.008

The role of neutrophil-to-lymphocyte ratio in left ventricular hypertrophy development in patients with comorbid course of hypertension, diabetes mellitus, and obesity

Oleksandra Babychevaa, Olga Sadovenkoa, Iulia Rodionovab, Inna Kutiab, Anton Bilchenkob, Borys Shelesta, Nataliia Sukhonosc, Yuliia Kovalovad
a Department of Internal and Occupational Diseases, Kharkiv National Medical University, Kharkiv, Ukraine
b Government Institution "L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine
c Municipal research institution "City Development Institute", Kyiv, Ukraine
d Department of Internal Medicine No. 2, Clinical Immunology and Allergology named after academician L.T. Malaya, Kharkiv National Medical University, Kharkiv, Ukraine

Objective: The patients with concurrent hypertension, diabetes mellitus (DM), and obesity are among the most common associated conditions in contemporary clinical practice. It is of crucial importance to investigate the development of left ventricular hypertrophy (LVH) in above mentioned complicated comorbid patients. The association of neutrophil-to-lymphocyte ratio (NLR) with the development of LVH is not researched enough. The aim of the work was to study the role of NLR in the development of LVH in hypertensive patients burdened with type 2 diabetes and obesity.

Methods: 297 hypertensive patients with diabetes mellitus type 2 and obesity were enrolled into the study. Two groups were created: the first group - LVH, n = 153, with left ventricular hypertrophy and the second one, n = 144, without the presence of LVH. The calculation of LV mass employed the modified Devereux formula, where values exceeding 95 g/m2 (females) and 115 g/m2 (males) were indicative of LVH. Data analysis

Keywords: Diabetes, Essential hypertension, Left ventricular hypertrophy, Neutrophil-to-lymphocyte ratio, Obesity,

Received: December 31, 2023; Revised: December 31, 2023; Accepted: January 30, 2024; Prepublished online: June 2, 2012; Published: June 28, 2024  Show citation

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Babycheva O, Sadovenko O, Rodionova I, Kutia I, Bilchenko A, Shelest B, et al.. The role of neutrophil-to-lymphocyte ratio in left ventricular hypertrophy development in patients with comorbid course of hypertension, diabetes mellitus, and obesity. Cor Vasa. 2024;66(3):328-334. doi: 10.33678/cor.2024.008.
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