Cor Vasa 2024, 66(3):323-327 | DOI: 10.33678/cor.2024.004

Early-LVT Risk Score - A new Clinical Risk Score for Early Left Ventricular Thrombus Prediction Following AnteriorST-Segment Elevation Myocardial Infarction

Joana Laranjeira Correiaa, *, Vanda Devesa Netoa, b, *, João Gouveia Fiuzaa, Luísa Gonçalvesa
a Centro Hospitalar Tondela-Viseu, Viseu, Portugal
b Universidade da Beira Interior, Covilhã, Portugal
* Both authors contributed equally to this work.

Background: Despite advancements in the management of ST-segment elevation myocardial infarction (STEMI), the risk of left ventricular thrombus (LVT) remains a significant concern due to its potential for embolic complications. Early identification of patients at high risk for LVT is crucial for guiding therapeutic interventions and improving clinical outcomes.

Aim: This study aimed to develop a practical and clinically applicable risk score (Early-LVT Risk Score) that integrates readily available demographic, clinical, and echocardiographic parameters to predict the likelihood of early LVT formation post anterior STEMI.

Methods: A sub-analysis of a single-center randomized controlled trial was conducted among patients with anterior STEMI and performed echocardiography in the first seven days following the event. Demographical, clinical, and diagnostic data were collected. The newly designed score was calculated for each patient, after identification of the variables significantly associated with LVT formation (points attributed for each variable according to odds ratio). The score incorporates age, clinical presentation (Killip-Kimball classification), history of previous myocardial infarction and echocardiographic findings (apical aneurysm). ROC curve analysis was performed to evaluate the predictive value of the score.

Keywords: Anterior myocardial infarction, Left ventricular thrombus, Risk score, ST-elevation myocardial infarction,

Received: December 19, 2023; Revised: January 3, 2024; Accepted: January 6, 2024; Prepublished online: June 4, 2024; Published: June 28, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Laranjeira Correia J, Devesa Neto V, Gouveia Fiuza J, Gonçalves L. Early-LVT Risk Score - A new Clinical Risk Score for Early Left Ventricular Thrombus Prediction Following AnteriorST-Segment Elevation Myocardial Infarction. Cor Vasa. 2024;66(3):323-327. doi: 10.33678/cor.2024.004.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Levine GN, McEvoy JW, Fang JC, et al. Management of Patients at Risk for and With Left Ventricular Thrombus: A Scientific Statement From the American Heart Association. Circulation 2022;146:e205-e223. Go to original source... Go to PubMed...
    2. Camaj A, Fuster V, Giustino G, et al. Left Ventricular Thrombus Following Acute Myocardial Infarction. J Am Coll Cardiol 2022;79:1010-1022. Go to original source... Go to PubMed...
    3. Rehan A, Kanwar M, Rosman H, et al. Incidence of post myocardial infarction left ventricular thrombus formation in the era of primary percutaneous intervention and glycoprotein IIb/IIIa inhibitors. A prospective observational study. Cardiovasc Ultrasound 2006;4:20. Go to original source... Go to PubMed...
    4. Ali Z, Isom N, Dalia T, et al. Direct oral anticoagulant use in left ventricular thrombus. Thromb J 2020;18:29. Go to original source... Go to PubMed...
    5. Gianstefani S, Douiri A, Delithanasis I, et al. Incidence and Predictors of Early Left Ventricular Thrombus After ST--Elevation Myocardial Infarction in the Contemporary Era of Primary Percutaneous Coronary Intervention. Am J Cardiol 2014;113:1111-1116. Go to original source... Go to PubMed...
    6. Kobayashi N, Maehar A. Left anterior descending artery wrapping around the left ventricular apex predicts additional risk of future events after anterior myocardial infarction. Anatol J Cardiol 2019;21:259-260. Go to original source... Go to PubMed...
    7. Delewi R, Zijlstra F, Piek JJ. Left ventricular thrombus formation after acute myocardial infarction. Heart 2019;98:1743-1749. Go to original source... Go to PubMed...
    8. Habash F, Vallurupalli S. Challenges in management of left ventricular thrombus. Ther Adv Cardiovasc Dis 2017;11:203-213. Go to original source... Go to PubMed...
    9. Abdelmoneim SS, Pellikka PA, Mulvagh SL. Contrast echocardiography for assessment of left ventricular thrombi.J Ultrasound Med 2014;33:1337-1344. Go to original source... Go to PubMed...
    10. Huang L, Tan Y, Pan Y. Systematic review of efficacy of direct oral anticoagulants and vitamin K antagonists in left ventricular thrombus. ESC Heart Fail 2022;9:3519-3532. Go to original source... Go to PubMed...
    11. Rodriguez JBC, Okajima K, Greenberg BH. Management of left ventricular thrombus: a narrative review. Ann Transl Med 2021;9:520. Go to original source... Go to PubMed...
    12. Massussi M, Scotti A, Lip GYH, et al. Left ventricular thrombosis: new perspectives on an old problem. Eur Heart J Cardiovasc Pharmacother 2020;7:158-167. Go to original source... Go to PubMed...
    13. Niazi AK, Kassem H, Shalaby G, et al. Incidence and Predictors of Left Ventricular (LV) Thrombus after ST-Elevation Myocardial Infarction (STEMI) in the Holy Capital of Saudi Arabia. J Saudi Heart Assoc 2021;33:101-108. Go to original source... Go to PubMed...
    14. Albaeni A, Chatila K, Beydoun HA, et al. In-hospital left ventricular thrombus following ST-elevation myocardial infarction. Int J Cardiol 2020;299:1-6. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content


    Cor et Vasa

    You are accessing a site intended for medical professionals, not the lay public. The site may also contain information that is intended only for persons authorized to prescribe and dispense medicinal products for human use.

    I therefore confirm that I am a healthcare professional under Act 40/1995 Coll. as amended by later regulations and that I have read the definition of a healthcare professional.


    No
    Yes