Cor Vasa 2023, 65(6):843-847 | DOI: 10.33678/cor.2023.067

DNA methylation and coronary artery disease: Brief summary of the main findings

Asma Amrani-Midoun^{a, b}, Nadia Laredj^c, Farouk Boukerche^c

^a Biotechnology Department, Faculty of Sciences of Nature and Life, University of Oran 1 Ahmed Benbella, Algeria

^b Medical Biochemistry and Molecular Biology Laboratory, Faculty of Medicine, University of Oran 1 Ahmed Benbella, Algeria

^c Cardiology Department, Faculty of Medicine, University Hospital Center of Oran, University of Oran 1 Ahmed Benbella, Algeria

Cardiovascular disease (CVD) and more specifically coronary artery disease (CAD) continue to be the leading cause of mortality worldwide. Many genetic factors have been identified to contribute to the risk of develop-ing CAD. However, the etiology and pathophysiology of complex diseases such as CAD are driven not only by genetic factors but also by the interaction between genetic and environmental factors. Therefore, research-ers are now exploring the epigenome, a biological interface at which genetics and the environment can interact. DNA methylation is the main epigenetic form of gene regulation, and it is increasingly recognized to play an important role in cardiovascular disease. Thus, we aim in this short review to summarize the main recent studies on the eventual contribution of DNA methylation status in the onset of CAD.

Keywords: Cardiovascular disease, Coronary artery disease, DNA methylation, Epigenetics

Received: August 10, 2023; Revised: August 10, 2023; Accepted: September 5, 2023; Prepublished online: June 2, 2012; Published: December 22, 2023  Show citation