Cor Vasa 2023, 65(4):624-630 | DOI: 10.33678/cor.2022.143

Is there a relationship between aortic valve degeneration and left ventricle function?

Aysel Akhundova, Murat Sunbul, Tarik Kivrak, Fuad Samadov, Bulent Mutlu
Department of Cardiology, Marmara University Hospital, Faculty of Medicine, Istanbul, Turkey

Purpose: The aim of the study was to explore the association between aortic valve (AV) degeneration and left ventricular (LV) functions and its relation with biomarkers.

Methods: Forty-two consecutive patients with degenerative AV disease and 25 controls were included. Degenerative AV were divided into stenotic and sclerotic valves. All patients underwent a two-dimensional (2D) transthoracic echocardiography and 2D speckle tracking echocardiography (STE) before and after semi-supine bicycle exercise test. We also evaluated the association between aortic sclerosis and biomarkers such as galactine-3, high-sensitive (hs) troponin-T, C-reactive protein (CRP) and pro-BNP.

Results: LV global longitudinal strain (GLS) was significantly impaired in degenerative AV patients than control at peak exercise and recovery period. Left atrial reservoir and conduit functions were also significantly impaired in degenerative AV patients than control at basal, peak exercise, and recovery period. CRP, hs-troponin T, and pro-BNP were significantly higher in degenerative valve groups than controls. LV-GLS was inversely correlated with CRP levels, E/e' at peak exercise, mean transvalvular aortic pressure gradients at rest and peak exercise. Multivariate linear regression analysis revealed that CRP levels and mean transvalvular aortic pressure gradients at peak exercise were independent predictors of LV-GLS at peak exercise.

Conclusions: Despite normal LV function, LV-GLS is not only significantly impaired in patients with aortic sclerosis but also the impairment is more pronounced during peak exercise. Results of the present study suggest that STE is a reliable tool in early detection on LV impairment in patients with aortic sclerosis. Klíčové slovo: Degenerace aortální chlopně

Keywords: Aortic valve degeneration

Received: November 25, 2022; Revised: November 25, 2022; Accepted: December 28, 2022; Prepublished online: September 27, 2023; Published: September 1, 2023  Show citation

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Akhundova A, Sunbul M, Kivrak T, Samadov F, Mutlu B. Is there a relationship between aortic valve degeneration and left ventricle function? Cor Vasa. 2023;65(4):624-630. doi: 10.33678/cor.2022.143.
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