Cor Vasa 2023, 65(1):65-67 | DOI: 10.33678/cor.2022.050

Is the microRNA-221/222 Cluster Ushering in a New Age of Cardiovascular Diseases?

Lutfu Askin, Okan Tanriverdi
Department of Cardiology, Adiyaman Education and Research Hospital, Adiyaman, Turkey

In addition to regulating gene expression, microRNAs (MiRs) regulate messenger RNA degradation and translation rates. MiRs have a high expression in the cardiovascular (CV) system, indicating an important role in vascular health. The atherosclerotic process has been related to miRs-221 and -222. MiRs-221/222 possess anti-stenotic activity. MiR-221/222 may potentially serve as a marker for myocardial remodeling. There is still a long way yet before miRs-221/222 can be recognized as a potential therapeutic target. Identification, validation, and understanding of the function of gene targets are all critical.

Keywords: Anti-stenotic activity, Cardiovascular system, MicroRNAs, MiRs-221/222, Myocardial remodeling,

Received: April 2, 2022; Revised: April 2, 2022; Accepted: April 30, 2022; Published: March 1, 2023  Show citation

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Askin L, Tanriverdi O. Is the microRNA-221/222 Cluster Ushering in a New Age of Cardiovascular Diseases? Cor Vasa. 2023;65(1):65-67. doi: 10.33678/cor.2022.050.
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