Cor Vasa 2021, 63(6):646-650 | DOI: 10.33678/cor.2021.022

Coronary ostial assessment of myeloperoxidase level correlated to severity of coronary artery disease

Noha Hassanin Hanboly^a, Yasser Kamel Gaber Baghdady^a, Mohammed Helmy Aly Ahmed^b, Assem Abdelaziz Hashad^a

^a Cardiovascular Department, Faculty of Medicine, Cairo University, Cairo, Egypt

^b Faculty of Medicine, Cairo University, Cairo, Egypt

Background: Myeloperoxidase participates in proatherogenic biological activities related to the evolution of cardiovascular disease including initiation, propagation, and acute complications of atherosclerotic process. Aim of study: We aimed to identify the relationship between myeloperoxidase (MPO) level at the ostium of coronary arteries and severity of coronary artery disease (CAD) .

Methods: Our study population was divided into two groups: group A and B. Group A included 43 patients with non-ST elevation myocardial infarction (NSTEMI) who underwent coronary angiography. Group B included 43 subjects free from CAD as proved by stress ECG or stress thallium study. MPO level was assessed by coronary osteal sampling of CAD group and peripheral venous sampling of both groups. The severity of CAD was studied using the Gensini & CASS scores.

Results: There was a significant difference in MPO level between both groups (p = 0.002) . Serum MPO was correlated to coronary artery disease as evaluated using Gensini score (p = 0.002) & CASS score (p = 0.05). Peripheral venous sample of MPO correlated with coronary osteal samples in CAD group.

Conclusions: Serum MPO was correlated to severity of coronary artery disease. The peripheral venous level of MPO reflected the osteal coronary levels of MPO. Coronary ostium is a simple, accessible and reliable site for coronary sampling.

Keywords: Acute coronary syndrome, Coronary blood sampling, Gensisi score, Myeloperoxidase

Received: December 8, 2020; Revised: December 8, 2020; Accepted: February 7, 2021; Published: December 13, 2021  Show citation