Cor Vasa 2021, 63(4):486-493 | DOI: 10.33678/cor.2021.041

(Cardiac troponins: current data on the diagnostic value and analytical characteristics of new determination methods)

Aleksey M. Chaulin^{a, b}, Dmitry V. Duplyakov^{a, b}

^a Samarská regionální klinická kardiologická léčebna, Státní rozpočtový ústav zdravotní péče, Samara, Rusko

^b Samarská státní lékařská univerzita, Federální státní rozpočtová vzdělávací instituce Ministerstva zdravotnictví Ruska, Samara, Rusko

The high levels of prevalence, morbidity, and mortality from cardiovascular diseases (CVDs) encourage researchers to conduct further research to find new biomarkers and improve methods of determining old biomarkers to optimize early diagnosis of CVDs. Relatively recently, new highly and ultrasensitive methods of cardiac troponin determination have been introduced into clinical practice, where the key advantage is the possibility of making an early optimal decision on the choice of further management tactics for patients admitted to the emergency department with chest pain. Currently, a considerable number of highly sensitive methods for determining cardiac troponins have been developed, which significantly differ in their qualitative characteristics. This article summarizes current information on the biology and diagnostic value of cardiac troponins and the analytical characteristics of highly sensitive determination methods.

Keywords: 99th percentil, Circadian features, Cardiac troponins, Cardiovascular diseases, Coefficient of variation

Received: January 19, 2021; Revised: March 26, 2021; Accepted: March 29, 2021; Published: August 25, 2021  Show citation