Cor Vasa 2021, 63(4):430-434 | DOI: 10.33678/cor.2021.012

Increased CRP/albumin ratio is associated with superficial venous reflux disease and varicose vein formation

Orcun Unala, Didem Melis Oztasb, Metin Onur Beyazc, Ibrahim Erdincd, Mert Merice, Mustafa Ozer Ulukanf, Atalay Karakayaf, Fatma Nihan Turhan Caglarg, Murat Ugurlucanf
a Cardiovascular Surgery Clinic, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey
b Cardiovascular Surgery Clinic, Istanbul Training and Research Hospital, Istanbul, Turkey
c Department of Cardiovascular Surgery, Hatay Mustafa Kemal University Medical Faculty, Hatay, Turkey
d Cardiovascular Surgery Clinic, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey
e Department of Cardiovascular Surgery, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey
f Department of Cardiovascular Surgery, Istanbul Medipol University Medical Faculty, Istanbul, Turkey
g Cardiology Clinic, Bakirkoy Training and Research Hospital, Istanbul, Turkey

Background: It has been recently postulated that inflammation may have an effect on varicose vein development and prognosis, besides increased venous pressure. CRP/albumin (CAR) is a novel inflammatory marker associated with poor prognosis in a various group of patients. Our aim in this study was to investigate the relation between varicose greater saphenous vein (VSM) diameter and CAR.

Methods: A total of 150 patients with patients VSM insufficiency (Group 1, n: 114) and normal VSM (n: 36) were included in the study. The diameter of the VSM was measured with B-mode ultrasound, and reflux was quantified based on valve closure time using Doppler spectral tracings. Blood samples were taken during recruitment. The CAR value is determined by dividing the serum CRP level to the albumin level.

Results: There were 21 (18.4%) males and 93 (81.5%) females in Group 1 and 7 males and 29 females in Group 2. Mean age of the patients were similar in both groups (48.02±12.20 years in Group 1 vs. 44.9±8.92 years in Group 2, p = 0.44). Mean BMI of the patients did not differ significantly (Group 1: 26.4±3.7 kg/m2

Keywords: Albumin, CRP, Inflammation, Superficial venous reflux disease

Received: December 15, 2020; Revised: December 15, 2020; Accepted: January 11, 2021; Published: August 25, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Unal O, Melis Oztas D, Beyaz MO, Erdinc I, Meric M, Ozer Ulukan M, et al.. Increased CRP/albumin ratio is associated with superficial venous reflux disease and varicose vein formation. Cor Vasa. 2021;63(4):430-434. doi: 10.33678/cor.2021.012.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Joh JH, Park HC. The cutoff value of saphenous vein diameter to predict reflux. J Korean Surg Soc 2013;85:169-174. Go to original source... Go to PubMed...
    2. Shah DM, Chang BB, Leopold PW, et al. The anatomy of the greater saphenous venous system. J Vasc Surg 1986;3:273-283. Go to original source...
    3. Grudzińska E, Lekstan A, Szliszka E, Czuba ZP. Cytokines Produced by Lymphocytes in the Incompetent Great Saphenous Vein. Mediators Inflamm 2018;2018:7161346. Go to original source... Go to PubMed...
    4. Lattimer CR, Kalodiki E, Geroulakos G, et al. Are Inflammatory Biomarkers Increased in Varicose Vein Blood? Clin Appl Thromb Hemost 2016;22:656-664. Go to original source... Go to PubMed...
    5. Park JE, Chung KS, Song JH, et al. The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients. J Clin Med 2018;7:333. Go to original source... Go to PubMed...
    6. Poredos P, Spirkoska A, Rucigaj T, et al. Do blood constituents in varicose veins differ from the systemic blood constituents? Eur J Vasc Endovasc Surg 2015;50:250-256. Go to original source... Go to PubMed...
    7. Poredoš P, Spirkoska A, Ježovnik MK. In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate. Arch Med Sci 2019;15:393-401. Go to original source... Go to PubMed...
    8. Legendre C, Debure C, Meaume S, et al. Impact of protein deficiency on venous ulcer healing. J Vasc Surg 2008;48:688-693. Go to original source... Go to PubMed...
    9. Bayrak M. Predictive value of C-Reactive Protein/Albumin ratio in patients with chronic complicated diabetes mellitus. Pak J Med Sci 2019;35:1616-1621. Go to original source... Go to PubMed...
    10. Kayssi A, Pope M, Vucemilo I, Werneck C. Endovenous radiofrequency ablation for the treatment of varicose veins. Can J Surg 2015;58:85-86. Go to original source... Go to PubMed...
    11. Eberhardt RT, Raffetto JD. Chronic venous insufficiency. Circulation 2014;130:333-346. Go to original source... Go to PubMed...
    12. Mendes CA, Martins AA, Fukuda JM, et al. Randomized trial of radiofrequency ablation versus conventional surgery for superficial venous insufficiency: if you don't tell, they won't know. Clinics (Sao Paulo) 2016;71:650-656. Go to original source... Go to PubMed...
    13. Pocock ES, Alsaigh T, Mazor R, Schmid-Schönbein GW. Cellular and molecular basis of venous insufficiency. Vasc Cell 2014;6:24. Go to original source... Go to PubMed...
    14. Ortega MA, Asúnsolo Á, Leal J, et al. Implication of the PI3K/Akt/mTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging. Oxid Med Cell Longev 2018;2018:1495170. Go to original source... Go to PubMed...
    15. Serralheiro P, Soares A, Costa Almeida CM, Verde I. TGF-β1 in Vascular Wall Pathology: Unraveling Chronic Venous Insufficiency Pathophysiology. Int J Mol Sci 2017;18:2534. Go to original source... Go to PubMed...
    16. Beyaz M, Bozkurt E, Onalan M, et al. Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA. Arch Med Sci 2021;17.
    17. Karabağ Y, Çağdaş M, Rencuzogullari I, et al. Relationship between C-reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris. J Clin Lab Anal 2018;32:e22457.
    18. Seringec Akkececi N, Yildirim Cetin G, Gogebakan H, Acipayam C. The C-Reactive Protein/Albumin Ratio and Complete Blood Count Parameters as Indicators of Disease Activity in Patients with Takayasu Arteritis. Med Sci Monit 2019;25:1401-1409. Go to original source... Go to PubMed...
    19. Wang W, Ren D, Wang CS, et al. Prognostic efficacy of high-sensitivity C-reactive protein to albumin ratio in patients with acute coronary syndrome. Biomark Med 2019;13:811-820. Go to original source... Go to PubMed...
    20. Saharay M, Shields DA, Georgiannos SN, et al. Endothelial activation in patients with chronic venous disease. Eur J Vasc Endovasc Surg 1998;15:342-349. Go to original source... Go to PubMed...
    21. Mosmiller LT, Steele KN, Shrader CD, Petrone AB. Evaluation of Inflammatory Cell Biomarkers in Chronic Venous Insufficiency. Phlebology 2017;32:634-640. Go to original source... Go to PubMed...
    22. Karahan O, Yavuz C, Kankilic N, et al. Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency. Blood Coagulation & Fibrinolysis 2016;27:684-690. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content


    Cor et Vasa

    You are accessing a site intended for medical professionals, not the lay public. The site may also contain information that is intended only for persons authorized to prescribe and dispense medicinal products for human use.

    I therefore confirm that I am a healthcare professional under Act 40/1995 Coll. as amended by later regulations and that I have read the definition of a healthcare professional.


    No
    Yes