Cor Vasa 2020, 62(1):29-32 | DOI: 10.33678/cor.2019.074
Characteristics of hippocampus, cognitive functions, lipid profile, and severity of chronic heart failure in patients with coronary heart disease
- V.I. Razumovsky Saratov State Medical University, Saratov, Russia
Background: Currently, the relationship between the severity of chronic heart failure (CHF) and the main quantitative characteristics of the hippocampus, cognitive functions, and lipid profile components in pa- tients with coronary heart disease (CHD) is not clearly understood.
Materials and methods: Fifty patients with CHD and functional class (FC) II-IV CHF were examined. The study did not include patients who had severe medical conditions which could develop the morphological changes in the brain. In addition to the routine clinical tests, Doppler echocardiography and nuclear magnetic resonance imaging (MRI) of the brain were performed; the right and left hippocampal volumes and lengths as well as the cortical gray matter thickness were calculated; N-terminal pro-B-type natriuretic peptide (NT-proBNP) and lipid panel components were measured. The cognitive functions were assessed via Wechsler Verbal and Nonverbal Scale of Ability (V and VII subtests) and Bourdon test (Dot Cancellation Test).
Results: The canonical correlation analysis revealed significant relationships between the groups of signs characterizing the severity of chronic heart failure parameters of the hippocampus, lipid profile components, and cognitive scores.
Keywords: Central nervous system, Chronic heart failure, Cognitive dysfunction, Hippocampus, Lipid profile
Received: September 10, 2019; Revised: September 10, 2019; Accepted: November 8, 2019; Published: February 28, 2020 Show citation
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