Cor Vasa 2025, 67(1):77-81 | DOI: 10.33678/cor.2024.063

High-Sensitivity Cardiac Troponin T Elevation and Paroxysmal Supraventricular Tachycardia. Is it Always Acute Coronary Syndrome?

Serena Miccichèa, Giuseppe Pelaggia, Maria Claudia Lo Nigroa, Simone Celestea, Alice Moncadaa, Olga La Cognataa, Armando Lo Savioa, Salvatore Bonannoa, Paolo Bellocchia, Graziella Agnellia, Alessio Curròb
a Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
b Cardiac Intensive Care, IRCCS - P.O Piemonte, Messina, Italy

Background: Paroxysmal supraventricular tachycardia (PSVT) is a common arrhythmia often presenting with symptoms mimicking acute coronary syndrome (ACS). Case presentation: We present a case of a 58-year-old man with PSVT accompanied by chest pain and elevated high-sensitivity troponin (hs-Tn) levels. Coronary angiography revealed slow coronary flow in absence of obstructive disease. The patient's symptoms resolved spontaneously, and echocardiographic findings normalized upon discharge.

Conclusions: This case underscores the diagnostic challenge of individuating ACS and highlights the transient troponin elevation seen in PSVT, potentially due to myocardial ischemia secondary to rapid heart rates. Clinical correlation and adjunctive diagnostic modalities are crucial in guiding management decisions, especially in the absence of significant coronary artery disease.

Keywords: Acute coronary syndrome, Chest pain, High-sensitive cardiac troponin, Myocardial ischemia, Paroxysmal supraventricular, tachycardia

Received: May 21, 2024; Revised: May 21, 2024; Accepted: August 14, 2024; Prepublished online: June 2, 2012; Published: March 1, 2025  Show citation

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Miccichè S, Pelaggi G, Lo Nigro MC, Celeste S, Moncada A, La Cognata O, et al.. High-Sensitivity Cardiac Troponin T Elevation and Paroxysmal Supraventricular Tachycardia. Is it Always Acute Coronary Syndrome? Cor Vasa. 2025;67(1):77-81. doi: 10.33678/cor.2024.063.
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References

  1. Brugada J, Katritsis DG, Arbelo E, et al; ESC Scientific Document Group. 2019 ESC Guidelines for the management of patients with supraventricular tachycardia. The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC). Eur Heart J 2020;41:655-720. Go to original source... Go to PubMed...
  2. Fiala M, Kautzner J, Táborský M. Doporučení ESC pro diagnostiku a léčbu pacientů se supraventrikulární tachykardií, 2019. Souhrn dokumentu připravený Českou kardiologickou společností. Cor Vasa 2020;62:141-152. Go to original source...
  3. González-Del-Hoyo M, Cediel G, Carrasquer A, et al. Prognostic implications of troponin I elevation in emergency department patients with tachyarrhythmia. Clin Cardiol 2019;42:546-552. Go to original source... Go to PubMed...
  4. Patanè S, Marte F, Sturiale M, et al. Atrial flutter, ventricular tachycardia and changing axis deviation associated with scleroderma. Int J Cardiol 2011;153:e25-e28. Go to original source... Go to PubMed...
  5. La Cognata O, Di Carlo A, Lo Savio A, et al. Ventricular tachycardia and non-Hodgkin's lymphoma. Syncope in a 33-year-old young. Cor Vasa 2023;65:783-786. Go to original source...
  6. Chen JL, Hsiao CH, Yen CC. Prognostic value of cardiac troponin in elderly patients with paroxysmal supraventricular tachycardia: A multicenter study. Am J Emerg Med 2023;69:167-172. Go to original source... Go to PubMed...
  7. Yetkin E, Ozturk S, Cuglan B, et al. Clinical presentation of paroxysmal supraventricular tachycardia: evaluation of usual and unusual symptoms. Cardiovasc Endocrinol Metab 2020;9:153-158. Go to original source... Go to PubMed...
  8. Luzza F, De Sarro R, Licordari R, et al. Atrial fibrillation and QT corrected. What is the best formula to use? Eur J Clin Invest 2023;53:e14013. Go to original source... Go to PubMed...
  9. Casale M, Correale M, Laterra G, et al. Effects of Sacubitril/Valsartan in Patients with High Arrhythmic Risk and an ICD: A Longitudinal Study. Clin Drug Investig 2021;41:169-176. Go to original source... Go to PubMed...
  10. Hashim TH, Shah J, Hashim AT, et al. The Drugs Used in the Treatment of Supraventricular Tachycardia in Pediatrics: A Systematic Review and Meta-Analysis. Cor Vasa 2023;65:477-484. Go to original source...
  11. Sayadnik M, Shafiee A, Jenab Y et al. Predictors of High-Sensitivity Cardiac Troponin T Elevation in Patients with Acute Paroxysmal Supraventricular Tachycardia and Ischemic Heart Disease. Tex Heart Inst J 2017;44:306-311. Go to original source... Go to PubMed...
  12. Peng G, Zei PC. Diagnosis and Management of Paroxysmal Supraventricular Tachycardia. JAMA 2024;331:601-610. Go to original source... Go to PubMed...
  13. Murer M, Cuculi F, Toggweiler S, et al. Elevated high-sensitivity troponin does not indicate the presence of coronary artery disease in patients presenting with supraventricular tachycardia. Cardiol J 2017;24:642-648. Go to original source... Go to PubMed...
  14. Hromádka M, Rajdl D, Trefil L, et al. Diagnostic sensitivity of high-sensitivity troponin T in acute myocardial infarction in patients with chest pain. Cor Vasa 2012;54:e227-e231. Go to original source...
  15. Patanè S, Marte F, Dattilo G, et al. Acute myocardial infarction and left bundle branch block with changing axis deviation. Int J Cardiol 2012;154:e47-e49. Go to original source... Go to PubMed...
  16. Dattilo G, Lamari A, Messina F, et al. The chance finding at multislice computed tomography coronary angiography of an ectopic origin of the left circumflex coronary artery from the right sinus of Valsalva. Int J Cardiol 2011;149:e43-e46. Go to original source... Go to PubMed...
  17. Aktaş H, Kaypakli O, Ozmen C, et al. Prognostic Value of High Sensitive Troponin T in Patients with Chronic Ischemic Heart Disease Undergoing Percutaneous Coronary Intervention. Cor Vasa 2021;63:32-39. Go to original source...
  18. Mierke J, Jellinghaus S, Selle A, et al. High-sensitive cardiac troponin T is not always heart - Paraneoplastic systemic sclerosis simulated myocardial ischemia. Cor Vasa 2018;60:e645-e648. Go to original source...
  19. Licordari R, Correale M, Bonanno S, et al. Beyond Natriuretic Peptides: Unveiling the Power of Emerging Biomarkers in Heart Failure. Biomolecules 2024;14:309. Go to original source... Go to PubMed...
  20. Jeremias A, Gibson CM. Narrative review: alternative causes for elevated cardiac troponin levels when acute coronary syndromes are excluded. Ann Intern Med 2005;142:786-791. Go to original source... Go to PubMed...
  21. Elikowski W, Baszko A, Wróblewski D, et al. Czestoskurcz nadkomorowy przyczyna podwyzszonego stezenia troponiny I u chorego z prawidłowymi tetnicami wieńcowymi [Supraventricular tachycardia as a cause of elevated troponin I in a patient with normal coronary arteries]. Pol Merkur Lekarski 2005;18:696-699. Polish.
  22. Pelikánová T. Diabetes mellitus and cardiovascular diseases. Cor Vasa 2011;53:242-248. Go to original source...
  23. Correale M, Lamacchia O, Ciccarelli M, et al. Vascular and metabolic effects of SGLT2i and GLP-1 in heart failure patients. Heart Fail Rev 2023;28:733-744. Go to original source... Go to PubMed...
  24. Dattilo G, Lamari A, Crosca S, et al. Correlation between insulin resistance and endothelial dysfunction assessed by flow-mediated dilation. Recenti Prog Med 2012;103:328-332.
  25. Vadivelu R, Vijayvergiya R. Panvascular risk factor - diabetes. Cor Vasa 2018;60:e18-e29. Go to original source...
  26. Vícha M, Skála T, Benešová K, et al. Review of non-insulin antidiabetic pharmacotherapy in patients with heart failure diabetes mellitus in the Czech Republic in 2018. Cor Vasa 2022;64:20-24. Go to original source...
  27. Şahan E, Kavurgaci S. The role of the CHA2DS2-VASc score as a venous thromboembolism predictor in cancer patients. Cor Vasa 2022;64:11-14. Go to original source...
  28. Alsancak Y, Sari H, Gurbuz AS, et al. CHA2DS2-VASc and HAS-BLED scores are not associated with cardiac defibrillators therapies. Cor Vasa 2021;63:304-311. Go to original source...
  29. Dattilo G, Falanga G, Casale M, et al. Oral Anticoagulants: Old and New Therapy. Advances in Medicine and Biology 2015;83:13-70.
  30. Shvets DA, Povetkin SV. Comparison of left ventricular deformity and twist parameters during Speckle Tracking with Philips iE33 and Affiniti 70 scanners. Cor Vasa 2021;63:661-667. Go to original source...
  31. Dattilo G, Imbalzano E, Lamari A, et al. Ischemic heart disease and early diagnosis. Study on the predictive value of 2D strain. Int J Cardiol 2016;215:150-156. Go to original source... Go to PubMed...
  32. Price S, Katz J, Kaufmann CC, Huber K. The year in cardiovascular medicine 2021: acute cardiovascular care and ischaemic heart disease. Cor Vasa 2022;64(Suppl. 4):79-86. Go to original source...
  33. Dattilo G, Laterra G, Licordari R, et al. The Long-Term Benefit of Sacubitril/Valsartan in Patients with HFrEF: A 5-Year Follow- -Up Study in a Real World Population. J Clin Med 2023;12:6247. Go to original source... Go to PubMed...
  34. Carluccio E, Dini FL, Correale M, et al. Effect of sacubitril/valsartan on cardiac remodeling compared with other renin--angiotensin system inhibitors: a difference-in-difference analysis of propensity-score matched samples. Clin Res Cardiol 2024;113:856-865. Go to original source... Go to PubMed...
  35. Ivascenko T, Voicehovskis VV, Voicehovska JG, et al. Oxidative stress, depression, and risk of recurrence of stable coronary heart disease. Cor Vasa 2021;63:555-563. Go to original source...
  36. Savarese G, Lindberg F, Christodorescu RM, et al. Physician perceptions, attitudes, and strategies towards implementing guideline-directed medical therapy in heart failure with reduced ejection fraction. A survey of the Heart Failure Association of the ESC and the ESC Council for Cardiology Practice. Eur J Heart Fail 2024;26:1408-1418. Go to original source... Go to PubMed...
  37. Zellweger MJ, Schaer BA, Cron TA, et al. Elevated troponin levels in absence of coronary artery disease after supraventricular tachycardia. Swiss Med Wkly 2003;133:439-441.
  38. Redfearn DP, Ratib K, Marshall HJ, et al. Supraventricular tachycardia promotes release of troponin I in patients with normal coronary arteries. Int J Cardiol 2005;102:521-522. Go to original source... Go to PubMed...
  39. Chaulin AM, Duplyakov DV. Moderní představy o mechanismech uvolňování srdečních troponinů a jejich diagnostické roli. Cor Vasa 2022;64:628-636. Go to original source...
  40. Newby LK, Jesse RL, Babb JD, et al. ACCF 2012 expert consensus document on practical clinical considerations in the interpretation of troponin elevations: a report of the American College of Cardiology Foundation task force on Clinical Expert Consensus Documents. J Am Coll Cardiol 2012;60:2427-2463. Go to original source... Go to PubMed...
  41. Yoo SM, Jang S, Kim JA, et al. Troponin-Positive Non-Obstructive Coronary Arteries and Myocardial Infarction with Non-Obstructive Coronary Arteries: Definition, Etiologies, and Role of CT and MR Imaging. Korean J Radiol 2020;21:1305-1316. Go to original source... Go to PubMed...
  42. Patanè S, Marte F, Di Bella G. Abnormal troponin I levels after supraventricular tachycardia. Int J Cardiol 2009;132:e57-e59. Go to original source... Go to PubMed...
  43. Ben Yedder N, Roux JF, Paredes FA. Troponin elevation in supraventricular tachycardia: primary dependence on heart rate. Can J Cardiol 2011;27:105-109. Go to original source... Go to PubMed...
  44. Mahajan N, Mehta Y, Rose M, et al. Elevated troponin level is not synonymous with myocardial infarction. Int J Cardiol 2006;111:442-449. Go to original source... Go to PubMed...
  45. Mierke J, Jellinghaus S, Selle A, et al. High-sensitive cardiac troponin T is not always heart - Paraneoplastic systemic sclerosis simulated myocardial ischemia. Cor Vasa 2018;60:e645-e648. Go to original source...
  46. Imbalzano E, Vatrano M, Mandraffino G, et al. Arterial stiffness as a predictor of recovery of left ventricular systolic function after acute myocardial infarction treated with primary percutaneous coronary intervention. Int J Cardiovasc Imaging 2015;31:1545-1551. Go to original source... Go to PubMed...
  47. Kanjwal K, Imran N, Grubb B, Kanjwal Y. Troponin elevation in patients with various tachycardias and normal epicardial coronaries. Indian Pacing Electrophysiol J 2008;8:172-174.
  48. Dorenkamp M, Zabel M, Sticherling C. Role of coronary angiography before radiofrequency ablation in patients presenting with paroxysmal supraventricular tachycardia. J Cardiovasc Pharmacol Ther 2007;12:137-144. Go to original source... Go to PubMed...
  49. Ede H, Ahmed HSSS, Mahfouz ASHG, et al. The Role of Coronary Computed Tomography Angiography in Evaluation of High Troponin Patients with Narrow-Complex Supraventricular Tachycardia. Heart Views 2021;22:249-255. Go to original source... Go to PubMed...
  50. Chow GV, Hirsch GA, Spragg DD, et al. Prognostic significance of cardiac troponin I levels in hospitalized patients presenting with supraventricular tachycardia. Medicine (Baltimore) 2010;89:141-148. Go to original source... Go to PubMed...
  51. Carlberg DJ, Tsuchitani S, Barlotta KS, et al. Serum troponin testing in patients with paroxysmal supraventricular tachycardia: outcome after ED care. Am J Emerg Med 2011;29:545-548. Go to original source... Go to PubMed...
  52. Xue F, Jiang TB, Jiang B, et al. Cardiac troponin I elevation with supraventricular tachycardia: two case reports and review of the literature. BMC Res Notes 2014;7:136. Go to original source... Go to PubMed...
  53. Thygesen K, Mair J, Katus H, et al. Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. Recommendations for the use of cardiac troponin measurement in acute cardiac care. Eur Heart J 2010;31:2197-2204. Go to original source... Go to PubMed...
  54. Jakubo V, Ondrúš T, Beňovská M, et al. Přehled a použití validovaných algoritmů využívajících vysoce senzitivní metodu stanovení srdečního troponinu k časné diagnostice akutního infarktu myokardu. Cor Vasa 2021;63:703-709. Go to original source...
  55. Hromádka M, Rajdl D, Trefil L, et al. Diagnostic sensitivity of high-sensitivity troponin T in acute myocardial infarction in patients with chest pain. Cor Vasa 2012;54:e227-e231. Go to original source...
  56. Peng G, Zei PC. Diagnosis and Management of Paroxysmal Supraventricular Tachycardia. JAMA 2024;331:601-610. Go to original source... Go to PubMed...

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