Cor Vasa 2023, 65(6):856-861 | DOI: 10.33678/cor.2023.055

Role of Corin in Cardiovascular Disease

Lutfu Askin, Fatih Poyraz
Department of Cardiology, Gaziantep Ersin Arslan Education and Research Hospital, Gaziantep, Turkey

Corin, a type II transmembrane serine protease present in significant amounts in the heart, activates natri-uretic peptides. Corin enters the circulation from myocytes. Hypertension, heart failure, myocardial infarction, preeclampsia, and stroke are linked to circulating soluble corin. Our results suggest that circulating soluble corin may be a sensitive and specific cardiovascular disease (CVD) risk and predictive biomarker. Unfortunately, circulating soluble corin is difficult to use clinically. This review summarizes recent corin and CVD studies and suggests future corin research to improve risk prediction, prognosis, and medical treatment of CVDs and encourage its use as a regular laboratory test.

Keywords: Cardiovascular disease, Corin, Heart failure, Hypertension

Received: May 19, 2023; Revised: May 19, 2023; Accepted: June 20, 2023; Prepublished online: June 2, 2012; Published: December 22, 2023  Show citation

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Askin L, Poyraz F. Role of Corin in Cardiovascular Disease. Cor Vasa. 2023;65(6):856-861. doi: 10.33678/cor.2023.055.
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