Cor Vasa 2023, 65(5):729-734 | DOI: 10.33678/cor.2023.054

Comparison of cyanoacrylate agents VariClose® and VenaSeal™ in the treatment of insufficient saphenous veins

Peter Baláža, b, c, Slavomír Rokošnýa, Adam Whitleya, d
a Division of Vascular Surgery, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic
b Cardiocentre, Third Faculty of Medicine, Charles University, Prague, Czech Republic
c Department of Vascular Surgery, National Institute of Cardiovascular Diseases, Bratislava, Slovak Republic
d Department of Anatomy, Second Faculty of Medicine, Charles University, Prague, Czech Republic

Objective: The goal of this study was to compare the cyanoacrylate venous sealing systems VenaSeal™ and VariClose® in the treatment of superficial venous insufficiency.

Methods: A single-centre retrospective analysis on patients treated between April 2018 and April 2022 with cyanoacrylate adhesives for lower limb superficial truncal vein insufficiency was performed.

Results: The VariClose® system was used in 27 patients (30 veins) and the VenaSeal™ system in 97 patients (125 veins). The median follow-up periods for patients treated with VariClose® and VenaSeal™ systems were 267 (IQR 223) and 201 (IQR 280) days, respectively. At one year, recanalization occurred in 11 veins treated with the VariClose® system and 5 veins treated with the VenaSeal™ system. The occlusion rates estimated by the Kaplan-Meier method at 30, 90, 180, and 360 days were 100%, 96%, 83%, and 42% for veins treated with the VariClose® system and 100%, 98%, 96%, and 91% for veins treated with the VenaSeal™ system (p <0.01).

Conclusions: The VenaSeal™ system had significantly better occlusion rates than the VariClose® system.

Keywords: Cyanoacrylate, VariClose®, Varicose veins, VenaSeal™ , Venous insufficiency

Received: February 17, 2023; Revised: June 14, 2023; Accepted: June 14, 2023; Published: October 15, 2023  Show citation

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Baláž P, Rokošný S, Whitley A. Comparison of cyanoacrylate agents VariClose® and VenaSeal™ in the treatment of insufficient saphenous veins. Cor Vasa. 2023;65(5):729-734. doi: 10.33678/cor.2023.054.
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