Cor Vasa 2023, 65(1):100-103 | DOI: 10.33678/cor.2022.085

Is the Atherogenic Index of Plasma (AIP) a Cardiovascular Disease Marker?

Lutfu Askina, Okan Tanriverdib
a Department of Cardiology, Gaziantep Islamic Science and Technology University, Gaziantep, Turkey
b Department of Cardiology, Adiyaman University, Adiyaman, Turkey

Numerous indicators have been used to diagnose and prognosticate cardiovascular disease (CVD). The atherogenic index of plasma (AIP) is a logarithmic conversion of triglyceride (TG) to high-density lipoprotein (HDL) molar concentrations. The close association between AIP and the size of lipoprotein particles may account for its excellent predictive value. AIP may be computed simply using a typical lipid profile. It is a bet- ter predictor of lipoprotein particle size than that of individual lipids or the ratio of TG to HDL.

Keywords: Atherogenic index of plasma, Cardiovascular disease, Ratio of triglyceride to high-density lipoprotein

Received: June 7, 2022; Revised: June 19, 2022; Accepted: July 25, 2022; Published: March 1, 2023  Show citation

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Askin L, Tanriverdi O. Is the Atherogenic Index of Plasma (AIP) a Cardiovascular Disease Marker? Cor Vasa. 2023;65(1):100-103. doi: 10.33678/cor.2022.085.
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    References

    1. Askin L, Askin HS, Tanriverdi O. The caveolin levels in cardiovascular disease. Cor Vasa 2021;63:579-582. Go to original source...
    2. Mensah GA, Brown DW. An overview of cardiovascular disease in the United States. Health Aff (Millwood) 2007;26:38-48. Go to original source... Go to PubMed...
    3. Kanthe PS, Patil BS, Bagali S, et al. Atherogenic Index as a Predictor of Cardiovascular Risk among Women with Different Grades of Obesity. IJCRIMPH 2012;4:1767-1774.
    4. Igweh JC, Nwagha IU, Okaro JM. The Effects of Menopause on the Serum lipid profile of Normal Females of South East Nigeria. Nig J Physiol Sci 2005;20:48-53.
    5. Mudhaffar SK. Atherogenic Index of Plasma (AIP) As a Parameter in Predicting Cardiovascular Risk in Males Compared To the Conventional Dyslipidemic Indices (Cholesterol Ratios). Karbala J Med 2013;6:1506-1513.
    6. Guerin M, Legoff W, Lassel TS, et al. Proatherogenic role of elevated CE transfer from HDL to VLDL and dense LDL in type 2 diabetics. Arterioscler Thromb Vasc Biol 2001;21:282-287. Go to original source... Go to PubMed...
    7. Manninen V, Tenkanen L, Koshinen P, et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study: implications for treatment. Circulation 2002;85:37-45. Go to original source... Go to PubMed...
    8. Njajou O, Kanaya AM, Holvoet P, et al. Association between oxidized LDL-C, obesity and type 2 diabetes. Diabetes Metab Res Rev 2009;25:733-739. Go to original source... Go to PubMed...
    9. Daniels LB, Laughlin G, Sarno MJ. Lp- PLA2 is an independent predictor of incident coronary heart disease in apparently healthy older population. J Am Coll Cardiol 2008;51:913-919. Go to original source... Go to PubMed...
    10. Ali Rajab TM. Comparative study for Atherogenic Index of Plasma (AIP) in patient with type 1 Diabetes Mellitus, type 2 Diabetes Mellitus, Betathalassemia and Hypothyroidism. Int J Chem Res 2012;2.
    11. Dobiášová M, Frohlich J, Šedová M, et al. Cholesterol esterification and atherogenic index of plasma correlate withlipoprotein size and findings on coronary angiography. J Lipid Res 2011;52:566-571. Go to original source... Go to PubMed...
    12. Dobiášová M, Frohlich J. The plasma parameter log (TG/HDL) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER HDL). Clin Biochem 2001;34:583-588. Go to original source... Go to PubMed...
    13. Dobiasova M. AIP - atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice. Vnitr Lek 2006;52:64-71. Go to PubMed...
    14. Flier JS. Biology of Obesity. In: Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL. eds. Harrison's Principles of Internal Medicine.17th ed. New York, NY: McGraw-Hill; 2008:462-464.
    15. Kavitha G, Ramani G, Dhass PK, Aruna RM. Oxidative stress, interleukin (il-6) and atherogenic index of plasma in diabetic nephropathy. I JABPT 2011;2:211-217.
    16. Wassink AM, Graaf VG, Sabita Y, et al. Metabolic syndrome and incidence of type 2 diabetes in patients with manifest vascular disease. Diabetes Vasc Dis Res 2008;5:114-122. Go to original source... Go to PubMed...
    17. Dobiasova M, Urbanova Z, Samanek M. Relation between particle size of HDL and LDL Lipoproteins and cholesterol Esterification rate. Physiol Res 2005;54;159-165. Go to original source...
    18. Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, et al. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran 2015;29:240. Go to PubMed...
    19. Fernandez-Macias JC, Ochoa-Martinez AC, Varela-Silva JA, PerezMaldonado IN. Atherogenic index of plasma: novel predictive biomarker for cardiovascular illnesses. Arch Med Res 2019;50:285-294. Go to original source... Go to PubMed...
    20. Kammar-Garcia A, Lopez-Moreno P, Hernandez-Hernandez ME, et al. Atherogenic index of plasma as a marker of cardiovascular risk factors in Mexicans aged 18 to 22 years. Proc (Bayl Univ Med Cent) 2020;34:22-27. Go to original source... Go to PubMed...
    21. Noumegni SR, Nansseu JR, Bigna JJ, et al. Atherogenic index of plasma and 10-year risk of cardiovascular disease in adult Africans living with HIV infection: a crosssectional study from Yaounde, Cameroon. JRSM Cardiovasc Dis 2017;6:2048004017740478. Go to original source... Go to PubMed...
    22. Hammam N, Abdel-Wahab N, Gheita TA. Atherogenic index of plasma in women with rheumatoid arthritis and systemic lupus erythematosus: a 10-year potential predictor of cardiovascular disease. Curr Rheumatol Rev 2021;17:122-130. Go to original source... Go to PubMed...
    23. Ivanova EA, Myasoedova VA, Melnichenko AA, et al. Small dense low-density lipoprotein as biomarker for atherosclerotic diseases. Oxid Med Cell Longev 2017;2017:1273042. Go to original source... Go to PubMed...
    24. Wu J, Zhou Q, Wei Z, et al. Atherogenic Index of Plasma and Coronary Artery Disease in the Adult Population: A Meta-Analysis. Front Cardiovasc Med 2021;8:817441. Go to original source... Go to PubMed...
    25. Fernández-Macías JC, Ochoa-Martínez AC, Varela-Silva JA, Pérez-Maldonado IN. Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses. Arch Med Res 2019;50:285-294. Go to original source... Go to PubMed...
    26. Bikov A, Meszaros M, Kunos L, et al. Atherogenic Index of Plasma in Obstructive Sleep Apnoea. J Clin Med 2021;10:417. Go to original source... Go to PubMed...
    27. Cao B, Fan Z, Zhang Y, Li T. Independent association of severity of obstructive sleep apnea with lipid metabolism of atherogenic index of plasma (AIP) and apoB/apoAI ratio. Sleep Breath 2020;24:1507-1513. Go to original source... Go to PubMed...
    28. Liu H, Liu K, Pei L, et al. Atherogenic Index of Plasma Predicts Outcomes in Acute Ischemic Stroke. Front Neurol 2021;12:741754. Go to original source... Go to PubMed...
    29. Kim JJ, Yoon J, Lee YJ, et al. Predictive Value of the Atherogenic Index of Plasma (AIP) for the Risk of Incident Ischemic Heart Disease among Non-Diabetic Koreans. Nutrients 2021;13:3231. Go to original source... Go to PubMed...
    30. Özcan AÖ, Yildirim A, Koyunsever NY, et al. Relationship between atherogenic index of plasma and stent thrombosis in patients with acute coronary syndrome. Anatol J Cardiol 2022;2:112-117. Go to original source... Go to PubMed...
    31. Shui X, Chen Z, Wen Z, et al. Association of Atherogenic Index of Plasma With Angiographic Progression in Patients With Suspected Coronary Artery Disease. Angiology 2022;73:927-935. Go to original source... Go to PubMed...
    32. Yi Q, Ren Z, Bai G, et al. The longitudinal effect of the atherogenic index of plasma on type 2 diabetes in middle-aged and older Chinese. Acta Diabetol 2022;59:269-279. Go to original source... Go to PubMed...
    33. Shin HR, Song S, Cho JA, Ly SY. Atherogenic Index of Plasma and Its Association with Risk Factors of Coronary Artery Disease and Nutrient Intake in Korean Adult Men: The 2013-2014 KNHANES. Nutrients 2022;14:1071. Go to original source... Go to PubMed...
    34. Fu L, Zhou Y, Sun J, et al. Atherogenic index of plasma is associated with major adverse cardiovascular events in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 2021;20:201. Go to original source... Go to PubMed...
    35. Zhou K, Qin Z, Tian J, et al. The Atherogenic Index of Plasma: A Powerful and Reliable Predictor for Coronary Artery Disease in Patients With Type 2 Diabetes. Angiology 2021;72:934-941. Go to original source... Go to PubMed...
    36. Zheng Y, Li C, Yang J, et al. Atherogenic index of plasma for non-diabetic, coronary artery disease patients after percutaneous coronary intervention: a prospective study of the long-term outcomes in China. Cardiovasc Diabetol 2022;21:29. Go to original source... Go to PubMed...
    37. Fernández-Aparicio Á, Perona JS, Schmidt-RioValle J, Padez C, González-Jiménez E. Assessment of Different Atherogenic Indices as Predictors of Metabolic Syndrome in Spanish Adolescents. Biol Res Nurs 2022;24:163-171. Go to original source... Go to PubMed...
    38. Wang L, Chen F, Xiaoqi C, et al. Atherogenic Index of Plasma Is an Independent Risk Factor for Coronary Artery Disease and a Higher SYNTAX Score. Angiology 2021;72:181-186. Go to original source... Go to PubMed...

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