Cor Vasa 2022, 64(1):46-52 | DOI: 10.33678/cor.2021.105

(Cardiovascular complications in acromegaly)

Ivana Ságová^{a, b}, Daniela Kantárová^b, Marián Mokáň^b, Milan Dragula^c, Peter Vaňuga^a

^a Endokrinologické oddelenie, Národný endokrinologický a diabetologický ústav n.o., Ľubochňa, Slovensko

^b I. interná klinika, Jesseniova lekárska fakulta v Martine a Univerzitná nemocnica Martin, Martin, Slovensko

^c Kardiologické oddelenie, Univerzitná nemocnica Martin, Martin, Slovensko

Acromegaly is a rare, chronic, progressive disease which is usually caused by a pituitary adenoma. Long-term presence of elevated growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels accompanying this disease is associated with rheumatologic, cardiovascular, pulmonary and metabolic complica- tions. Cardiovascular disorders are the leading cause of morbidity and mortality in patients with acromegaly. Cardiovascular complications of acromegaly include an arterial hypertension, cardiomyopathy, arrhytmias, valvulopathy as well as endothelial dysfunction. The diagnosis of acromegaly has been delayed for several years due to slow progression of symptoms. Early diagnosis and treatment of the disease is necessary to prevent chronic cardiovascular damage.

Keywords: Acromegaly, Cardiovascular complications, Growth hormone, Insulin-like growth factor 1

Received: August 18, 2021; Revised: August 18, 2021; Accepted: August 26, 2021; Published: February 22, 2022  Show citation