Cor Vasa 2025, 67(1):48-55 | DOI: 10.33678/cor.2024.081

Spontaneous Coronary Artery Dissection in Patients with COVID-19: A Systematic Review of Published Case Reports

Andriantoa, Chabib F. Albabb, Nabila R. Putrib, Pratista Oktafiab, Roy B. Kurniawanb
a Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Indonesia
b Faculty of Medicine, Universitas Airlangga, Indonesia

Background: Spontaneous coronary artery dissection (SCAD) presents a unique challenge due to its prompt diagnosis and treatment requirements, demanding an in-depth understanding of its underlying mechanisms. This systematic review aims to provide a comprehensive summary of the SCAD cases in patients diagnosed with COVID-19.

Methods: We performed a systematic search across databases, including PubMed, ScienceDirect, and Cochrane, on June 3, 2023. We included reported cases of SCAD in COVID-19 patients that described individual patient data.

Results: The study analyzed 12 case reports, revealing that all patients were confirmed COVID-19 cases with a median age of 49, predominantly female (58.3%). Most exhibited classic COVID-19 symptoms (66.7%), with severe presentations observed in those with a pregnancy history. High HS troponin levels were common (83.3%), as were ECG changes, namely ST and T abnormality. Coronary angiography was the primary diagnostic tool (91.7%), with the left anterior descending artery (LAD) being the most common site of dissection (50%). Four cases had reduced ejection fraction, but no cardiovascular complications occurred post-management. This study elaborates on the characteristics of SCAD in COVID-19 patients, and appropriate modalities and treatments were observed.

Keywords: COVID-19, Diagnosis, Spontaneous coronary artery dissection, Treatment

Received: August 2, 2024; Revised: August 2, 2024; Accepted: October 11, 2024; Prepublished online: June 2, 2012; Published: March 1, 2025  Show citation

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Andrianto, Albab CF, Putri NR, Oktafia P, Kurniawan RB. Spontaneous Coronary Artery Dissection in Patients with COVID-19: A Systematic Review of Published Case Reports. Cor Vasa. 2025;67(1):48-55. doi: 10.33678/cor.2024.081.
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