Cor Vasa 2021, 63(6):737-740 | DOI: 10.33678/cor.2021.137

(Ferric carboxymaltose - a promising molecule in the treatment of iron deficiency in patients with heart failure)

Mária Bakošováa, b, Jan Krejčía, b, Lenka Špinarováa, b
a I. interní kardioangiologická klinika, Fakultní nemocnice u sv. Anny v Brně, Brno
b Lékařská fakulta Masarykovy univerzity, Brno

The authors summarize the new findings on iron deficiency in patients with heart failure recently reflected in the new guidelines for the management of the heart failure. In addition to recapitulating previous evidence, they discuss the results of the AFFIRM-HF trial, which extended the indication of ferric carboxymaltose to patients after acute decompensation of heart failure. It has been shown that after intravenous iron supplementation there is an improvement in symptoms, performance and a reduction in hospital admissions for heart failure decompensation. The text is supplemented by a case report describing the case of a 60-year-old female patient with heart failure of ischemic etiology who was found to be iron deficient when her condition worsened, and there was a significant improvement in symptomatology after intravenous administration of ferric carboxymaltose. The case report is followed by a review of our own experience in monitoring and treating iron deficiency in patients with heart failure.

Keywords: Anemia, Ferric carboxymaltose, Ferritin, Heart failure, Iron deficiency, Transferrin saturation

Received: December 4, 2021; Accepted: December 4, 2021; Published: December 13, 2021  Show citation

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Bakošová M, Krejčí J, Špinarová L. (Ferric carboxymaltose - a promising molecule in the treatment of iron deficiency in patients with heart failure). Cor Vasa. 2021;63(6):737-740. doi: 10.33678/cor.2021.137.
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References

  1. Anand IS, Gupta P. Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies. Circulation 2018;138:80-98. Go to original source... Go to PubMed...
  2. Iorio A, Senni M, Barbati G, et al. Prevalence and prognostic impact of non-cardiac co-morbidities in heart failure outpatients with preserved and reduced ejection fraction: a community-based study. Eur J Heart Fail 2018;20:1257-1266. Go to original source... Go to PubMed...
  3. Kassebaum NJ, Jasrasaria R, Naghavi M, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood 2014;123:615-624. Go to original source... Go to PubMed...
  4. Camaschella C. Iron deficiency. Blood 2019;133:30-39. Go to original source... Go to PubMed...
  5. Melenovsky V, Petrak J, Mracek T, et al. Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. Eur J Heart Fail 2017;19:522-530. Go to original source... Go to PubMed...
  6. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003;102:783-788. Go to original source... Go to PubMed...
  7. Nemeth E, Ganz T. The Role of Hepcidin in Iron Metabolism. Acta Haematol 2009;122:78-86. Go to original source... Go to PubMed...
  8. Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-2093. Go to original source... Go to PubMed...
  9. van der Wal HH, Grote Beverborg N, Dickstein K, et al. Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use. Eur Heart J 2019;40:3616-3625. Go to original source... Go to PubMed...
  10. Okonko DO, Mandal AK, Missouris CG, Poole-Wilson PA. Disordered iron homeostasis in chronic heart failure:prevalence, predictors, and relation to anemia, exercise capacity, and survival. J Am Coll Cardiol 2011;58:1241-1251. Go to original source... Go to PubMed...
  11. McDonagh T, Damy T, Doehner W, et al. Screening, diagnosis and treatment of iron deficiency in chronic heart failure: putting the 2016 European Society of Cardiology heart failure guidelines into clinical practice. Eur J Heart Fail 2018;20:1664-1672. Go to original source... Go to PubMed...
  12. Cappellini MD, Comin-Colet J, de Francisco A, et al.; IRON CORE Group. Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management. Am J Hematol 2017;92:1068-1078. Go to original source... Go to PubMed...
  13. Špinar J, Hradec J, Špinarová L, Vítovec J. Summary of the 2016 ESC Guidelines on the diagnosis and treatment of acute and chronic heart failure. Prepared by the Czech Society of Cardiology. Cor Vasa 2016;58:e530-e568. Go to original source...
  14. McDonagh TA, Metra M, Adamo M, et al., ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2021;42:3599-3726. Go to original source... Go to PubMed...
  15. Ponikowski P, Kirwan BA, Anker SD, et al. Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial, Lancet 2020;396:1895-1904. Go to original source... Go to PubMed...

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