Cor Vasa 2017, 59(2):e174-e176 | DOI: 10.1016/j.crvasa.2016.05.001
An unexpected complication. First descriptions of intercostal artery rupture in Ehlers-Danlos syndrome
- Technische Universität Dresden, Heart Center, University Hospital, Department of Internal Medicine and Cardiology, Dresden, Germany
A case of Ehlers-Danlos syndrome of vascular type with a history of mechanical valve prosthesis was admitted with dyspnea and chest pain. After exclusion a myocardial infarction, an angio-CT was performed and revealed a spontaneous rupture of an intercostal artery with subsequent hemothorax and compression atelectasis. The case was complicated by the ongoing anticoagulant therapy for the mechanical valve prosthesis with warfarin. After failure of conservative therapy, the case underwent surgical treatment. As shown in this case, mechanical valve prosthesis with necessary adequate anticoagulation, using long lasting warfarin derivates, could be an unneeded added risk for these patients.
Keywords: Anticoagulation; Aortic valve replacement; Ascending aorta aneurysm; Ehlers-Danlos syndrome; Intercostal artery rupture; Mechanical heart valve
Received: April 16, 2016; Accepted: May 4, 2016; Published: April 1, 2017 Show citation
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References
- J.R. Mao, J. Bristow, The Ehlers-Danlos syndrome: on beyond collagens, The Journal of Clinical Investigation 107 (2001) 1063-1069.
Go to original source... 
Go to PubMed... - D.P. Germain, Ehlers-Danlos syndrome type IV, Orphanet Journal of Rare Diseases 2 (2007) 32. Go to original source... Go to PubMed...
- M. Pepin, U. Schwarze, A. Superti-Furga, P.H. Byers, Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type, New England Journal of Medicine 342 (2000) 673-680. Go to original source... Go to PubMed...
- D.R. Brinster, R.J. Rizzo, R.M. Bolman III, Ascending aortic aneurysms, in: L.H. Cohn (Ed.), Cardiac Surgery in the Adult, 3rd ed., McGraw-Hill, New York, NY, 2008, 1223.
- S.A. Jaffe, M.E. Geltman, E.G. Rodey, J. Uitto, Mitral valve prolapse: a consistent manifestation of type IV Ehlers-Danlos syndrome. The pathogenetic role of the abnormal production of type III collagen, Circulation 64 (1981) 121-125. Go to original source... Go to PubMed...