Cor Vasa 2008, 50(5):191-194 | DOI: 10.33678/cor.2008.065

Sensitivity and specificity of stress cardiac gated SPECT imaging in the detection of coronary artery disease: validation of findings by coronary angiography.

Iva Metelková1, Milan Kamínek1, Jiří Ostřanský2, Miroslava Budíková1, Marek Richter2, Martin Sluka2, Jarmila Indráková2, Eliška Sovová2, Jan Lukl2
1 Klinika nukleární medicíny
2 I. interní klinika, Fakultní nemocnice Olomouc a Lékařská fakulta Univerzity Palackého, Olomouc, Česká republika

Aim:
The aim of this study was to analyze the sensitivity and specificity of cardiac gated SPECT imaging and to assess the diagnostic potential of quantitative perfusion and the left ventricular function parameters to identify high-risk patients with multivessel coronary artery disease (CAD).

Methods:
582 patients (412 men, mean age 62 ± 10 years, 164 after previous myocardial infarction, 125 after revascula-rization) underwent a stress gated SPECT study followed by coronary angiography. A summed stress score (SSS), post-stress and rest left ventricular ejection fraction (LVEF) and transient ischemic dilatation ratio (TID) were obtained through the use of 4D-MSPECT software.

Results:
In visual assessment, the sensitivity and specificity of SPECT were 93% (389/417), and 79% (130/165), respectively. In quantitative perfusion analysis, SSS rose with the number of diseased vessels: SSS were 9, 13 and 16 in patients with 1-, 2- and 3-vessel disease, respectively. We observed signs of postischemic left ventricular stunning (worsening of LVEF by exercise > 5% and/or TID ratio > 1.17) in 46%, 52%, and 66% of patients with 1-, 2-, and 3-vessel disease, respectively.

Conclusion:
Quantitative perfusion and function parameters (high SSS or signs of postischemic stunning) enable the identification of high-risk patients with multivessel CAD.

Keywords: Cardiac gated SPECT; Multivessel coronary artery disease; Postischemic left ventricular stunning

Published: May 1, 2008  Show citation

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Metelková I, Kamínek M, Ostřanský J, Budíková M, Richter M, Sluka M, et al.. Sensitivity and specificity of stress cardiac gated SPECT imaging in the detection of coronary artery disease: validation of findings by coronary angiography. Cor Vasa. 2008;50(5):191-194. doi: 10.33678/cor.2008.065.
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